RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner

BACKGROUND: Lymph node metastasis is the main cause of poor prognosis of head and neck squamous carcinoma (HNSCC) patients. N6-methyladenosine (m6A) RNA modification is an emerging epigenetic regulatory mechanism for gene expression, and as a novel m6A reader protein, IGF2BP2 has been implicated in...

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Detalles Bibliográficos
Autores principales: Yu, Dan, Pan, Min, Li, Yanshi, Lu, Tao, Wang, Zhihai, Liu, Chuan, Hu, Guohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722037/
https://www.ncbi.nlm.nih.gov/pubmed/34980207
http://dx.doi.org/10.1186/s13046-021-02212-1

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