Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets

BACKGROUND: DNA repair deficiencies are characteristic of cancer and homologous recombination deficiency (HRD) is the most common. HRD sensitizes tumour cells to PARP inhibitors so it is important to understand the landscape of HRD across different solid tumour types. METHODS: Germline and somatic B...

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Detalles Bibliográficos
Autores principales: Lai, Zhongwu, Brosnan, Matthew, Sokol, Ethan S., Xie, Mingchao, Dry, Jonathan R., Harrington, Elizabeth A., Barrett, J. Carl, Hodgson, Darren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722117/
https://www.ncbi.nlm.nih.gov/pubmed/34979999
http://dx.doi.org/10.1186/s12885-021-09082-y

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