High genetic heterogeneity of Mycobacterium intracellulare isolated from respiratory specimens

BACKGROUND: M. intracellulare is a frequent causative pathogen of nontuberculous mycobacteria infection that causes infections in the respiratory tract, whose incidence is increasing in many countries. This study aimed at determining the VNTR-based genetic diversity of a collection of 39 M. intracel...

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Autores principales: Lari, Nicoletta, Rindi, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722163/
https://www.ncbi.nlm.nih.gov/pubmed/34979921
http://dx.doi.org/10.1186/s12866-021-02426-5
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author Lari, Nicoletta
Rindi, Laura
author_facet Lari, Nicoletta
Rindi, Laura
author_sort Lari, Nicoletta
collection PubMed
description BACKGROUND: M. intracellulare is a frequent causative pathogen of nontuberculous mycobacteria infection that causes infections in the respiratory tract, whose incidence is increasing in many countries. This study aimed at determining the VNTR-based genetic diversity of a collection of 39 M. intracellulare human strains isolated from respiratory specimens over the last 5 years. RESULTS: The VNTR analysis showed that M. intracellulare strains displayed a high genetic diversity, indicating that the M. intracellulare genotypes are quite heterogeneous in our geographical area. Moreover, a comparison with VNTR profiles of strains from other countries confirmed that genotypes of clinical strains of M. intracellulare are not related to geographical origin. CONCLUSIONS: VNTR typing has proved to be a highly discriminatory method for better understanding the molecular epidemiology of M. intracellulare.
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spelling pubmed-87221632022-01-06 High genetic heterogeneity of Mycobacterium intracellulare isolated from respiratory specimens Lari, Nicoletta Rindi, Laura BMC Microbiol Research BACKGROUND: M. intracellulare is a frequent causative pathogen of nontuberculous mycobacteria infection that causes infections in the respiratory tract, whose incidence is increasing in many countries. This study aimed at determining the VNTR-based genetic diversity of a collection of 39 M. intracellulare human strains isolated from respiratory specimens over the last 5 years. RESULTS: The VNTR analysis showed that M. intracellulare strains displayed a high genetic diversity, indicating that the M. intracellulare genotypes are quite heterogeneous in our geographical area. Moreover, a comparison with VNTR profiles of strains from other countries confirmed that genotypes of clinical strains of M. intracellulare are not related to geographical origin. CONCLUSIONS: VNTR typing has proved to be a highly discriminatory method for better understanding the molecular epidemiology of M. intracellulare. BioMed Central 2022-01-03 /pmc/articles/PMC8722163/ /pubmed/34979921 http://dx.doi.org/10.1186/s12866-021-02426-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Lari, Nicoletta
Rindi, Laura
High genetic heterogeneity of Mycobacterium intracellulare isolated from respiratory specimens
title High genetic heterogeneity of Mycobacterium intracellulare isolated from respiratory specimens
title_full High genetic heterogeneity of Mycobacterium intracellulare isolated from respiratory specimens
title_fullStr High genetic heterogeneity of Mycobacterium intracellulare isolated from respiratory specimens
title_full_unstemmed High genetic heterogeneity of Mycobacterium intracellulare isolated from respiratory specimens
title_short High genetic heterogeneity of Mycobacterium intracellulare isolated from respiratory specimens
title_sort high genetic heterogeneity of mycobacterium intracellulare isolated from respiratory specimens
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722163/
https://www.ncbi.nlm.nih.gov/pubmed/34979921
http://dx.doi.org/10.1186/s12866-021-02426-5
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