Homozygous mutation in SLO3 leads to severe asthenoteratozoospermia due to acrosome hypoplasia and mitochondrial sheath malformations

BACKGROUND: Potassium channels are important for the structure and function of the spermatozoa. As a potassium transporter, the mSlo3 is essential for male fertility as Slo3 knockout male mice were infertile with the series of functional defects in sperm cells. However, no pathogenic variant has bee...

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Detalles Bibliográficos
Autores principales: Lv, Mingrong, Liu, Chunyu, Ma, Chunjie, Yu, Hui, Shao, Zhongmei, Gao, Yang, Liu, Yiyuan, Wu, Huan, Tang, Dongdong, Tan, Qing, Zhang, Junqiang, Li, Kuokuo, Xu, Chuan, Geng, Hao, Zhang, Jingjing, Li, Hang, Mao, Xiaohong, Ge, Lei, Fu, Feifei, Zhong, Kaixin, Xu, Yuping, Tao, Fangbiao, Zhou, Ping, Wei, Zhaolian, He, Xiaojin, Zhang, Feng, Cao, Yunxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722334/
https://www.ncbi.nlm.nih.gov/pubmed/34980136
http://dx.doi.org/10.1186/s12958-021-00880-4

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