Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer

Protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of apoptosis, proliferation, and DNA-damage response, is overexpressed in many cancers, including small cell lung cancer (SCLC). Here we report that LB100, a small molecule inhibitor of PP2A, when combined with...

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Detalles Bibliográficos
Autores principales: Mirzapoiazova, Tamara, Xiao, Gang, Mambetsariev, Bolot, Nasser, Mohd W., Miaou, Emily, Singhal, Sharad S., Srivastava, Saumya, Mambetsariev, Isa, Nelson, Michael S., Nam, Arin, Behal, Amita, Atri, Pranita, Muschen, Markus, Tissot, François L.H., Miser, James, Kovach, John S., Sattler, Martin, Batra, Surinder K., Kulkarni, Prakash, Salgia, Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Small Molecule Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722383/
https://www.ncbi.nlm.nih.gov/pubmed/34253596
http://dx.doi.org/10.1158/1535-7163.MCT-21-0013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722383/
https://www.ncbi.nlm.nih.gov/pubmed/34253596
http://dx.doi.org/10.1158/1535-7163.MCT-21-0013

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