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Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network

Clostridioides difficile infection is widespread throughout countries and represents an important cause of nosocomial diarrhoea, with relatively high morbidity. This infection often occurs in patients with inflammatory bowel diseases and may complicate their clinical picture. Here, we propose, on th...

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Autores principales: Bassotti, Gabrio, Fruganti, Alessandro, Maconi, Giovanni, Marconi, Pierfrancesco, Fettucciari, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722535/
https://www.ncbi.nlm.nih.gov/pubmed/35002278
http://dx.doi.org/10.2147/JIR.S328628
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author Bassotti, Gabrio
Fruganti, Alessandro
Maconi, Giovanni
Marconi, Pierfrancesco
Fettucciari, Katia
author_facet Bassotti, Gabrio
Fruganti, Alessandro
Maconi, Giovanni
Marconi, Pierfrancesco
Fettucciari, Katia
author_sort Bassotti, Gabrio
collection PubMed
description Clostridioides difficile infection is widespread throughout countries and represents an important cause of nosocomial diarrhoea, with relatively high morbidity. This infection often occurs in patients with inflammatory bowel diseases and may complicate their clinical picture. Here, we propose, on the basis of evidence from basic science studies, that in patients affected by inflammatory bowel diseases, this infection might be facilitated by a derangement of the enteric glial cell (EGC) network caused by the effects of proinflammatory cytokines, such as tumour necrosis factor alpha and interferon gamma, which enhance the cytotoxic effects of C. difficile toxin B on EGCs. This hypothesis, if confirmed, could open the door to alternative treatment approaches to fight C. difficile infection.
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spelling pubmed-87225352022-01-06 Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network Bassotti, Gabrio Fruganti, Alessandro Maconi, Giovanni Marconi, Pierfrancesco Fettucciari, Katia J Inflamm Res Perspectives Clostridioides difficile infection is widespread throughout countries and represents an important cause of nosocomial diarrhoea, with relatively high morbidity. This infection often occurs in patients with inflammatory bowel diseases and may complicate their clinical picture. Here, we propose, on the basis of evidence from basic science studies, that in patients affected by inflammatory bowel diseases, this infection might be facilitated by a derangement of the enteric glial cell (EGC) network caused by the effects of proinflammatory cytokines, such as tumour necrosis factor alpha and interferon gamma, which enhance the cytotoxic effects of C. difficile toxin B on EGCs. This hypothesis, if confirmed, could open the door to alternative treatment approaches to fight C. difficile infection. Dove 2021-12-30 /pmc/articles/PMC8722535/ /pubmed/35002278 http://dx.doi.org/10.2147/JIR.S328628 Text en © 2021 Bassotti et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Perspectives
Bassotti, Gabrio
Fruganti, Alessandro
Maconi, Giovanni
Marconi, Pierfrancesco
Fettucciari, Katia
Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network
title Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network
title_full Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network
title_fullStr Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network
title_full_unstemmed Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network
title_short Clostridioides difficile Infection in Patients with Inflammatory Bowel Disease May be Favoured by the Effects of Proinflammatory Cytokines on the Enteroglial Network
title_sort clostridioides difficile infection in patients with inflammatory bowel disease may be favoured by the effects of proinflammatory cytokines on the enteroglial network
topic Perspectives
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722535/
https://www.ncbi.nlm.nih.gov/pubmed/35002278
http://dx.doi.org/10.2147/JIR.S328628
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