Temporal associations of B and T cell immunity with robust vaccine responsiveness in a 16-week interval BNT162b2 regimen

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Spacing of the BNT162b2 mRNA doses beyond 3 weeks raised concerns about vaccine efficacy. We longitudinally analyzed B cell, T cell and humoral responses to two BNT162b2 mRNA doses administered 16 weeks apart in 53 SARS-CoV-2 naïve and previously-infected donors. This regimen elicited robust RBD-spe...

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Autores principales: Nayrac, Manon, Dubé, Mathieu, Sannier, Gérémy, Nicolas, Alexandre, Marchitto, Lorie, Tastet, Olivier, Tauzin, Alexandra, Brassard, Nathalie, Beaudoin-Bussières, Guillaume, Vézina, Dani, Gong, Shang Yu, Benlarbi, Mehdi, Gasser, Romain, Laumaea, Annemarie, Bourassa, Catherine, Gendron-Lepage, Gabrielle, Medjahed, Halima, Goyette, Guillaume, Ortega-Delgado, Gloria-Gabrielle, Laporte, Mélanie, Niessl, Julia, Gokool, Laurie, Morrisseau, Chantal, Arlotto, Pascale, Richard, Jonathan, Tremblay, Cécile, Martel-Laferrière, Valérie, Finzi, Andrés, Kaufmann, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722583/
https://www.ncbi.nlm.nih.gov/pubmed/34981046
http://dx.doi.org/10.1101/2021.12.18.473317

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