A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

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Effective drugs against SARS-CoV-2 are urgently needed to treat severe cases of infection and for prophylactic use. The main viral protease (nsp5 or 3CLpro) represents an attractive and possibly broad-spectrum target for drug development as it is essential to the virus life cycle and highly conserve...

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Detalles Bibliográficos
Autores principales: Chen, KY, Krischuns, T, Ortega Varga, L, Harigua-Souiai, E, Paisant, S, Zettor, A, Chiaravalli, J, Courtney, D, O’Brien, A, Baker, SC, Isel, C, Agou, F, Jacob, Y, Blondel, A, Naffakh, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722588/
https://www.ncbi.nlm.nih.gov/pubmed/34981051
http://dx.doi.org/10.1101/2021.12.18.473303
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