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The Gompertz Growth of COVID-19 Outbreaks is Caused by Super-Spreaders

In individual SARS-CoV-2 outbreaks, the count of confirmed cases and deaths follow a Gompertz growth function for locations of very different sizes. This lack of dependence on region size leads us to hypothesize that virus spread depends on universal properties of the network of social interactions....

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Autores principales: Zonta, Francesco, Scaiewicz, Andrea, Levitt, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cornell University 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722603/
https://www.ncbi.nlm.nih.gov/pubmed/34981031
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author Zonta, Francesco
Scaiewicz, Andrea
Levitt, Michael
author_facet Zonta, Francesco
Scaiewicz, Andrea
Levitt, Michael
author_sort Zonta, Francesco
collection PubMed
description In individual SARS-CoV-2 outbreaks, the count of confirmed cases and deaths follow a Gompertz growth function for locations of very different sizes. This lack of dependence on region size leads us to hypothesize that virus spread depends on universal properties of the network of social interactions. We test this hypothesis by simulating the propagation of a virus on networks of different topologies. Our main finding is that Gompertz growth observed for early outbreaks occurs only for a scale-free network, in which nodes with many more neighbors than average are common. These nodes that have very many neighbors are infected early in the outbreak and then spread the infection very rapidly. When these nodes are no longer infectious, the remaining nodes that have most neighbors take over and continue to spread the infection. In this way, the rate of spread is fastest at the very start and slows down immediately. Geometrically it is seen that the “surface” of the epidemic, the number of susceptible nodes in contact with the infected nodes, starts to rapidly decrease very early in the epidemic and as soon as the larger nodes have been infected. In our simulation, the speed and impact of an outbreak depend on three parameters: the average number of contacts each node makes, the probability of being infected by a neighbor, and the probability of recovery. Intelligent interventions to reduce the impact of future outbreaks need to focus on these critical parameters in order to minimize economic and social collateral damage.
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spelling pubmed-87226032022-01-04 The Gompertz Growth of COVID-19 Outbreaks is Caused by Super-Spreaders Zonta, Francesco Scaiewicz, Andrea Levitt, Michael ArXiv Article In individual SARS-CoV-2 outbreaks, the count of confirmed cases and deaths follow a Gompertz growth function for locations of very different sizes. This lack of dependence on region size leads us to hypothesize that virus spread depends on universal properties of the network of social interactions. We test this hypothesis by simulating the propagation of a virus on networks of different topologies. Our main finding is that Gompertz growth observed for early outbreaks occurs only for a scale-free network, in which nodes with many more neighbors than average are common. These nodes that have very many neighbors are infected early in the outbreak and then spread the infection very rapidly. When these nodes are no longer infectious, the remaining nodes that have most neighbors take over and continue to spread the infection. In this way, the rate of spread is fastest at the very start and slows down immediately. Geometrically it is seen that the “surface” of the epidemic, the number of susceptible nodes in contact with the infected nodes, starts to rapidly decrease very early in the epidemic and as soon as the larger nodes have been infected. In our simulation, the speed and impact of an outbreak depend on three parameters: the average number of contacts each node makes, the probability of being infected by a neighbor, and the probability of recovery. Intelligent interventions to reduce the impact of future outbreaks need to focus on these critical parameters in order to minimize economic and social collateral damage. Cornell University 2021-11-03 /pmc/articles/PMC8722603/ /pubmed/34981031 Text en https://creativecommons.org/licenses/by-nc-sa/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (https://creativecommons.org/licenses/by-nc-sa/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
spellingShingle Article
Zonta, Francesco
Scaiewicz, Andrea
Levitt, Michael
The Gompertz Growth of COVID-19 Outbreaks is Caused by Super-Spreaders
title The Gompertz Growth of COVID-19 Outbreaks is Caused by Super-Spreaders
title_full The Gompertz Growth of COVID-19 Outbreaks is Caused by Super-Spreaders
title_fullStr The Gompertz Growth of COVID-19 Outbreaks is Caused by Super-Spreaders
title_full_unstemmed The Gompertz Growth of COVID-19 Outbreaks is Caused by Super-Spreaders
title_short The Gompertz Growth of COVID-19 Outbreaks is Caused by Super-Spreaders
title_sort gompertz growth of covid-19 outbreaks is caused by super-spreaders
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722603/
https://www.ncbi.nlm.nih.gov/pubmed/34981031
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