Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles

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The Omicron SARS-CoV-2 virus contains extensive sequence changes relative to the earlier arising B.1, B.1.1 and Delta SARS-CoV-2 variants that have unknown effects on viral infectivity and response to existing vaccines. Using SARS-CoV-2 virus-like particles (SC2-VLPs), we examined mutations in all f...

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Detalles Bibliográficos
Autores principales: Syed, Abdullah M., Ciling, Alison, Khalid, Mir M., Sreekumar, Bharath, Chen, Pei-Yi, Kumar, G. Renuka, Silva, Ines, Milbes, Bilal, Kojima, Noah, Hess, Victoria, Shacreaw, Maria, Lopez, Lauren, Brobeck, Matthew, Turner, Fred, Spraggon, Lee, Taha, Taha Y., Tabata, Takako, Chen, Irene P., Ott, Melanie, Doudna, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722610/
https://www.ncbi.nlm.nih.gov/pubmed/34981067
http://dx.doi.org/10.1101/2021.12.20.21268048

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