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Prevention of mother-to-child transmission of hepatitis B virus in antenatal care and maternity services, Mozambique

OBJECTIVE: To pilot an intervention on the prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in an antenatal care and maternity unit in Maputo, Mozambique, during 2017–2019. METHODS: We included HBV in the existing screening programme (for human immunodeficiency virus (HI...

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Autores principales: Loarec, Anne, Nguyen, Aude, Molfino, Lucas, Chissano, Mafalda, Madeira, Natercia, Rusch, Barbara, Staderini, Nelly, Couto, Aleny, Ciglenecki, Iza, Antabak, Natalia Tamayo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Health Organization 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722623/
https://www.ncbi.nlm.nih.gov/pubmed/35017758
http://dx.doi.org/10.2471/BLT.20.281311
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author Loarec, Anne
Nguyen, Aude
Molfino, Lucas
Chissano, Mafalda
Madeira, Natercia
Rusch, Barbara
Staderini, Nelly
Couto, Aleny
Ciglenecki, Iza
Antabak, Natalia Tamayo
author_facet Loarec, Anne
Nguyen, Aude
Molfino, Lucas
Chissano, Mafalda
Madeira, Natercia
Rusch, Barbara
Staderini, Nelly
Couto, Aleny
Ciglenecki, Iza
Antabak, Natalia Tamayo
author_sort Loarec, Anne
collection PubMed
description OBJECTIVE: To pilot an intervention on the prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in an antenatal care and maternity unit in Maputo, Mozambique, during 2017–2019. METHODS: We included HBV in the existing screening programme (for human immunodeficiency virus (HIV) and syphilis) for pregnant women at their first consultation, and followed mother–child dyads until 9 months after delivery. We referred women who tested positive for hepatitis B surface antigen (HBsAg) for further tests, including hepatitis B e antigen (HBeAg) and HBV viral load. According to the results, we proposed tenofovir for their own health or for PMTCT. We administered birth-dose HBV vaccine and assessed infant HBV status at 9 months. FINDINGS: Of 6775 screened women, 270 (4.0%) were HBsAg positive; in those for whom data were available, 24/265 (9.1%) were HBeAg positive and 14/267 (5.2%) had a viral load of > 200 000 IU/mL. Ninety-eight (36.3%) HBsAg-positive women were HIV coinfected, 97 of whom were receiving antiretroviral treatment with tenofovir. Among HIV-negative women, four had an indication for tenofovir treatment and four for tenofovir PMTCT. Of 217 exposed liveborn babies, 181 (83.4%) received birth-dose HBV vaccine, 160 (88.4%) of these < 24 hours after birth. At the 9-month follow-up, only one out of the 134 tested infants was HBV positive. CONCLUSION: Our nurse-led intervention highlights the feasibility of integrating PMTCT of HBV into existing antenatal care departments, essential for the implementation of the triple elimination initiative. Universal birth-dose vaccination is key to achieving HBV elimination.
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spelling pubmed-87226232022-01-10 Prevention of mother-to-child transmission of hepatitis B virus in antenatal care and maternity services, Mozambique Loarec, Anne Nguyen, Aude Molfino, Lucas Chissano, Mafalda Madeira, Natercia Rusch, Barbara Staderini, Nelly Couto, Aleny Ciglenecki, Iza Antabak, Natalia Tamayo Bull World Health Organ Research OBJECTIVE: To pilot an intervention on the prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) in an antenatal care and maternity unit in Maputo, Mozambique, during 2017–2019. METHODS: We included HBV in the existing screening programme (for human immunodeficiency virus (HIV) and syphilis) for pregnant women at their first consultation, and followed mother–child dyads until 9 months after delivery. We referred women who tested positive for hepatitis B surface antigen (HBsAg) for further tests, including hepatitis B e antigen (HBeAg) and HBV viral load. According to the results, we proposed tenofovir for their own health or for PMTCT. We administered birth-dose HBV vaccine and assessed infant HBV status at 9 months. FINDINGS: Of 6775 screened women, 270 (4.0%) were HBsAg positive; in those for whom data were available, 24/265 (9.1%) were HBeAg positive and 14/267 (5.2%) had a viral load of > 200 000 IU/mL. Ninety-eight (36.3%) HBsAg-positive women were HIV coinfected, 97 of whom were receiving antiretroviral treatment with tenofovir. Among HIV-negative women, four had an indication for tenofovir treatment and four for tenofovir PMTCT. Of 217 exposed liveborn babies, 181 (83.4%) received birth-dose HBV vaccine, 160 (88.4%) of these < 24 hours after birth. At the 9-month follow-up, only one out of the 134 tested infants was HBV positive. CONCLUSION: Our nurse-led intervention highlights the feasibility of integrating PMTCT of HBV into existing antenatal care departments, essential for the implementation of the triple elimination initiative. Universal birth-dose vaccination is key to achieving HBV elimination. World Health Organization 2022-01-01 2021-12-02 /pmc/articles/PMC8722623/ /pubmed/35017758 http://dx.doi.org/10.2471/BLT.20.281311 Text en (c) 2022 The authors; licensee World Health Organization. https://creativecommons.org/licenses/by/3.0/igo/This is an open access article distributed under the terms of the Creative Commons Attribution IGO License (http://creativecommons.org/licenses/by/3.0/igo/legalcode (https://creativecommons.org/licenses/by/3.0/igo/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any reproduction of this article there should not be any suggestion that WHO or this article endorse any specific organization or products. The use of the WHO logo is not permitted. This notice should be preserved along with the article's original URL.
spellingShingle Research
Loarec, Anne
Nguyen, Aude
Molfino, Lucas
Chissano, Mafalda
Madeira, Natercia
Rusch, Barbara
Staderini, Nelly
Couto, Aleny
Ciglenecki, Iza
Antabak, Natalia Tamayo
Prevention of mother-to-child transmission of hepatitis B virus in antenatal care and maternity services, Mozambique
title Prevention of mother-to-child transmission of hepatitis B virus in antenatal care and maternity services, Mozambique
title_full Prevention of mother-to-child transmission of hepatitis B virus in antenatal care and maternity services, Mozambique
title_fullStr Prevention of mother-to-child transmission of hepatitis B virus in antenatal care and maternity services, Mozambique
title_full_unstemmed Prevention of mother-to-child transmission of hepatitis B virus in antenatal care and maternity services, Mozambique
title_short Prevention of mother-to-child transmission of hepatitis B virus in antenatal care and maternity services, Mozambique
title_sort prevention of mother-to-child transmission of hepatitis b virus in antenatal care and maternity services, mozambique
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722623/
https://www.ncbi.nlm.nih.gov/pubmed/35017758
http://dx.doi.org/10.2471/BLT.20.281311
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