Cargando…

Delirium, Caffeine, and Perioperative Cortical Dynamics

Delirium is a major public health issue associated with considerable morbidity and mortality, particularly after surgery. While the neurobiology of delirium remains incompletely understood, emerging evidence suggests that cognition requires close proximity to a system state called criticality, which...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hyoungkyu, McKinney, Amy, Brooks, Joseph, Mashour, George A., Lee, UnCheol, Vlisides, Phillip E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722672/
https://www.ncbi.nlm.nih.gov/pubmed/34987367
http://dx.doi.org/10.3389/fnhum.2021.744054
_version_ 1784625563193835520
author Kim, Hyoungkyu
McKinney, Amy
Brooks, Joseph
Mashour, George A.
Lee, UnCheol
Vlisides, Phillip E.
author_facet Kim, Hyoungkyu
McKinney, Amy
Brooks, Joseph
Mashour, George A.
Lee, UnCheol
Vlisides, Phillip E.
author_sort Kim, Hyoungkyu
collection PubMed
description Delirium is a major public health issue associated with considerable morbidity and mortality, particularly after surgery. While the neurobiology of delirium remains incompletely understood, emerging evidence suggests that cognition requires close proximity to a system state called criticality, which reflects a point of dynamic instability that allows for flexible access to a wide range of brain states. Deviations from criticality are associated with neurocognitive disorders, though the relationship between criticality and delirium has not been formally tested. This study tested the primary hypothesis that delirium in the postanesthesia care unit would be associated with deviations from criticality, based on surrogate electroencephalographic measures. As a secondary objective, the impact of caffeine was also tested on delirium incidence and criticality. To address these aims, we conducted a secondary analysis of a randomized clinical trial that tested the effects of intraoperative caffeine on postoperative recovery in adults undergoing major surgery. In this substudy, whole-scalp (16-channel) electroencephalographic data were analyzed from a subset of trial participants (n = 55) to determine whether surrogate measures of neural criticality – (1) autocorrelation function of global alpha oscillations and (2) topography of phase relationships via phase lag entropy – were associated with delirium. These measures were analyzed in participants experiencing delirium in the postanesthesia care unit (compared to those without delirium) and in participants randomized to caffeine compared to placebo. Results demonstrated that autocorrelation function in the alpha band was significantly reduced in delirious participants, which is important given that alpha rhythms are postulated to play a vital role in consciousness. Moreover, participants randomized to caffeine demonstrated increased alpha autocorrelation function concurrent with reduced delirium incidence. Lastly, the anterior-posterior topography of phase relationships appeared most preserved in non-delirious participants and in those receiving caffeine. These data suggest that early postoperative delirium may reflect deviations from neural criticality, and caffeine may reduce delirium risk by shifting cortical dynamics toward criticality.
format Online
Article
Text
id pubmed-8722672
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-87226722022-01-04 Delirium, Caffeine, and Perioperative Cortical Dynamics Kim, Hyoungkyu McKinney, Amy Brooks, Joseph Mashour, George A. Lee, UnCheol Vlisides, Phillip E. Front Hum Neurosci Human Neuroscience Delirium is a major public health issue associated with considerable morbidity and mortality, particularly after surgery. While the neurobiology of delirium remains incompletely understood, emerging evidence suggests that cognition requires close proximity to a system state called criticality, which reflects a point of dynamic instability that allows for flexible access to a wide range of brain states. Deviations from criticality are associated with neurocognitive disorders, though the relationship between criticality and delirium has not been formally tested. This study tested the primary hypothesis that delirium in the postanesthesia care unit would be associated with deviations from criticality, based on surrogate electroencephalographic measures. As a secondary objective, the impact of caffeine was also tested on delirium incidence and criticality. To address these aims, we conducted a secondary analysis of a randomized clinical trial that tested the effects of intraoperative caffeine on postoperative recovery in adults undergoing major surgery. In this substudy, whole-scalp (16-channel) electroencephalographic data were analyzed from a subset of trial participants (n = 55) to determine whether surrogate measures of neural criticality – (1) autocorrelation function of global alpha oscillations and (2) topography of phase relationships via phase lag entropy – were associated with delirium. These measures were analyzed in participants experiencing delirium in the postanesthesia care unit (compared to those without delirium) and in participants randomized to caffeine compared to placebo. Results demonstrated that autocorrelation function in the alpha band was significantly reduced in delirious participants, which is important given that alpha rhythms are postulated to play a vital role in consciousness. Moreover, participants randomized to caffeine demonstrated increased alpha autocorrelation function concurrent with reduced delirium incidence. Lastly, the anterior-posterior topography of phase relationships appeared most preserved in non-delirious participants and in those receiving caffeine. These data suggest that early postoperative delirium may reflect deviations from neural criticality, and caffeine may reduce delirium risk by shifting cortical dynamics toward criticality. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8722672/ /pubmed/34987367 http://dx.doi.org/10.3389/fnhum.2021.744054 Text en Copyright © 2021 Kim, McKinney, Brooks, Mashour, Lee and Vlisides. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Kim, Hyoungkyu
McKinney, Amy
Brooks, Joseph
Mashour, George A.
Lee, UnCheol
Vlisides, Phillip E.
Delirium, Caffeine, and Perioperative Cortical Dynamics
title Delirium, Caffeine, and Perioperative Cortical Dynamics
title_full Delirium, Caffeine, and Perioperative Cortical Dynamics
title_fullStr Delirium, Caffeine, and Perioperative Cortical Dynamics
title_full_unstemmed Delirium, Caffeine, and Perioperative Cortical Dynamics
title_short Delirium, Caffeine, and Perioperative Cortical Dynamics
title_sort delirium, caffeine, and perioperative cortical dynamics
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722672/
https://www.ncbi.nlm.nih.gov/pubmed/34987367
http://dx.doi.org/10.3389/fnhum.2021.744054
work_keys_str_mv AT kimhyoungkyu deliriumcaffeineandperioperativecorticaldynamics
AT mckinneyamy deliriumcaffeineandperioperativecorticaldynamics
AT brooksjoseph deliriumcaffeineandperioperativecorticaldynamics
AT mashourgeorgea deliriumcaffeineandperioperativecorticaldynamics
AT leeuncheol deliriumcaffeineandperioperativecorticaldynamics
AT vlisidesphillipe deliriumcaffeineandperioperativecorticaldynamics