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Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases

Long non-coding RNAs (lncRNAs) play important roles in human diseases. They control gene expression levels and influence various biological processes through multiple mechanisms. Functional abnormalities in lncRNAs are strongly associated with occurrence and development of various diseases. LINC0047...

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Autores principales: Ren, Dan-yang, Yuan, Xin-rong, Tu, Cai-xia, Shen, Jian-ling, Li, Yun-wei, Yan, Ai-hua, Ru, Yi, Han, Hui-yun, Yang, Yan-ming, Liu, Yan, Li, Hui-ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722734/
https://www.ncbi.nlm.nih.gov/pubmed/34987381
http://dx.doi.org/10.3389/fphar.2021.726908
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author Ren, Dan-yang
Yuan, Xin-rong
Tu, Cai-xia
Shen, Jian-ling
Li, Yun-wei
Yan, Ai-hua
Ru, Yi
Han, Hui-yun
Yang, Yan-ming
Liu, Yan
Li, Hui-ying
author_facet Ren, Dan-yang
Yuan, Xin-rong
Tu, Cai-xia
Shen, Jian-ling
Li, Yun-wei
Yan, Ai-hua
Ru, Yi
Han, Hui-yun
Yang, Yan-ming
Liu, Yan
Li, Hui-ying
author_sort Ren, Dan-yang
collection PubMed
description Long non-coding RNAs (lncRNAs) play important roles in human diseases. They control gene expression levels and influence various biological processes through multiple mechanisms. Functional abnormalities in lncRNAs are strongly associated with occurrence and development of various diseases. LINC00472, which is located on chromosome 6q13, is involved in several human diseases, particularly cancers of the breast, lung, liver, osteosarcoma, bladder, colorectal, ovarian, pancreatic and stomach. Importantly, LINC00472 can be used as a biomarker for breast cancer cell sensitivity to chemotherapeutic regimens, including doxorubicin. LINC00472 is regulated by microRNAs and several signaling pathways. However, the significance of LINC00472 in human diseases has not been clearly established. In this review, we elucidate on the significance of LINC00472 in various human diseases, indicating that LINC00472 may be a diagnostic, prognostic as well as therapeutic target for these diseases.
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spelling pubmed-87227342022-01-04 Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases Ren, Dan-yang Yuan, Xin-rong Tu, Cai-xia Shen, Jian-ling Li, Yun-wei Yan, Ai-hua Ru, Yi Han, Hui-yun Yang, Yan-ming Liu, Yan Li, Hui-ying Front Pharmacol Pharmacology Long non-coding RNAs (lncRNAs) play important roles in human diseases. They control gene expression levels and influence various biological processes through multiple mechanisms. Functional abnormalities in lncRNAs are strongly associated with occurrence and development of various diseases. LINC00472, which is located on chromosome 6q13, is involved in several human diseases, particularly cancers of the breast, lung, liver, osteosarcoma, bladder, colorectal, ovarian, pancreatic and stomach. Importantly, LINC00472 can be used as a biomarker for breast cancer cell sensitivity to chemotherapeutic regimens, including doxorubicin. LINC00472 is regulated by microRNAs and several signaling pathways. However, the significance of LINC00472 in human diseases has not been clearly established. In this review, we elucidate on the significance of LINC00472 in various human diseases, indicating that LINC00472 may be a diagnostic, prognostic as well as therapeutic target for these diseases. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8722734/ /pubmed/34987381 http://dx.doi.org/10.3389/fphar.2021.726908 Text en Copyright © 2021 Ren, Yuan, Tu, Shen, Li, Yan, Ru, Han, Yang, Liu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Ren, Dan-yang
Yuan, Xin-rong
Tu, Cai-xia
Shen, Jian-ling
Li, Yun-wei
Yan, Ai-hua
Ru, Yi
Han, Hui-yun
Yang, Yan-ming
Liu, Yan
Li, Hui-ying
Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases
title Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases
title_full Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases
title_fullStr Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases
title_full_unstemmed Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases
title_short Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases
title_sort long noncoding rna 00472: a novel biomarker in human diseases
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722734/
https://www.ncbi.nlm.nih.gov/pubmed/34987381
http://dx.doi.org/10.3389/fphar.2021.726908
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