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Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases
Long non-coding RNAs (lncRNAs) play important roles in human diseases. They control gene expression levels and influence various biological processes through multiple mechanisms. Functional abnormalities in lncRNAs are strongly associated with occurrence and development of various diseases. LINC0047...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722734/ https://www.ncbi.nlm.nih.gov/pubmed/34987381 http://dx.doi.org/10.3389/fphar.2021.726908 |
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author | Ren, Dan-yang Yuan, Xin-rong Tu, Cai-xia Shen, Jian-ling Li, Yun-wei Yan, Ai-hua Ru, Yi Han, Hui-yun Yang, Yan-ming Liu, Yan Li, Hui-ying |
author_facet | Ren, Dan-yang Yuan, Xin-rong Tu, Cai-xia Shen, Jian-ling Li, Yun-wei Yan, Ai-hua Ru, Yi Han, Hui-yun Yang, Yan-ming Liu, Yan Li, Hui-ying |
author_sort | Ren, Dan-yang |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) play important roles in human diseases. They control gene expression levels and influence various biological processes through multiple mechanisms. Functional abnormalities in lncRNAs are strongly associated with occurrence and development of various diseases. LINC00472, which is located on chromosome 6q13, is involved in several human diseases, particularly cancers of the breast, lung, liver, osteosarcoma, bladder, colorectal, ovarian, pancreatic and stomach. Importantly, LINC00472 can be used as a biomarker for breast cancer cell sensitivity to chemotherapeutic regimens, including doxorubicin. LINC00472 is regulated by microRNAs and several signaling pathways. However, the significance of LINC00472 in human diseases has not been clearly established. In this review, we elucidate on the significance of LINC00472 in various human diseases, indicating that LINC00472 may be a diagnostic, prognostic as well as therapeutic target for these diseases. |
format | Online Article Text |
id | pubmed-8722734 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-87227342022-01-04 Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases Ren, Dan-yang Yuan, Xin-rong Tu, Cai-xia Shen, Jian-ling Li, Yun-wei Yan, Ai-hua Ru, Yi Han, Hui-yun Yang, Yan-ming Liu, Yan Li, Hui-ying Front Pharmacol Pharmacology Long non-coding RNAs (lncRNAs) play important roles in human diseases. They control gene expression levels and influence various biological processes through multiple mechanisms. Functional abnormalities in lncRNAs are strongly associated with occurrence and development of various diseases. LINC00472, which is located on chromosome 6q13, is involved in several human diseases, particularly cancers of the breast, lung, liver, osteosarcoma, bladder, colorectal, ovarian, pancreatic and stomach. Importantly, LINC00472 can be used as a biomarker for breast cancer cell sensitivity to chemotherapeutic regimens, including doxorubicin. LINC00472 is regulated by microRNAs and several signaling pathways. However, the significance of LINC00472 in human diseases has not been clearly established. In this review, we elucidate on the significance of LINC00472 in various human diseases, indicating that LINC00472 may be a diagnostic, prognostic as well as therapeutic target for these diseases. Frontiers Media S.A. 2021-12-20 /pmc/articles/PMC8722734/ /pubmed/34987381 http://dx.doi.org/10.3389/fphar.2021.726908 Text en Copyright © 2021 Ren, Yuan, Tu, Shen, Li, Yan, Ru, Han, Yang, Liu and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Ren, Dan-yang Yuan, Xin-rong Tu, Cai-xia Shen, Jian-ling Li, Yun-wei Yan, Ai-hua Ru, Yi Han, Hui-yun Yang, Yan-ming Liu, Yan Li, Hui-ying Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases |
title | Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases |
title_full | Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases |
title_fullStr | Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases |
title_full_unstemmed | Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases |
title_short | Long Noncoding RNA 00472: A Novel Biomarker in Human Diseases |
title_sort | long noncoding rna 00472: a novel biomarker in human diseases |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8722734/ https://www.ncbi.nlm.nih.gov/pubmed/34987381 http://dx.doi.org/10.3389/fphar.2021.726908 |
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