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Kidney Transplantation From Deceased Donors With Bloodstream Infection: A Multicenter Retrospective Study

BACKGROUND: The use of organs from donors with infection is limited because of the possibility of transmission. We aimed to investigate the transmission after deceased donor transplantation with bloodstream infection (BSI). METHODS: A retrospective study of patients undergoing kidney or pancreas tra...

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Autores principales: Mo, Hyejin, Lee, Juhan, Park, Jae Berm, Park, Sun Cheol, Kim, Young Hoon, Han, Ahram, Jung, In Mok, Ha, Jongwon, Kim, Nam-Joong, Min, Sangil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723893/
https://www.ncbi.nlm.nih.gov/pubmed/34981680
http://dx.doi.org/10.3346/jkms.2022.37.e4
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author Mo, Hyejin
Lee, Juhan
Park, Jae Berm
Park, Sun Cheol
Kim, Young Hoon
Han, Ahram
Jung, In Mok
Ha, Jongwon
Kim, Nam-Joong
Min, Sangil
author_facet Mo, Hyejin
Lee, Juhan
Park, Jae Berm
Park, Sun Cheol
Kim, Young Hoon
Han, Ahram
Jung, In Mok
Ha, Jongwon
Kim, Nam-Joong
Min, Sangil
author_sort Mo, Hyejin
collection PubMed
description BACKGROUND: The use of organs from donors with infection is limited because of the possibility of transmission. We aimed to investigate the transmission after deceased donor transplantation with bloodstream infection (BSI). METHODS: A retrospective study of patients undergoing kidney or pancreas transplantation at five tertiary centers in Korea from January 2009 and November 2019 was performed. We analyzed the outcomes after transplantation from deceased donors with BSI. RESULTS: Eighty-six recipients received transplantation from 69 donors with BSI. The most common isolated pathogens from donors were Gram-positive bacteria (72.0%), followed by Gram-negative bacteria (22.7%), and fungi (5.3%). Appropriate antimicrobial agents were used in 47.8% of donors before transplantation. Transmission occurred only in 1 of 83 recipients (1.2%) from bacteremic donors and 1 of 6 recipients (16.7%) from fungemic donors. One-year patient and graft survival was 97.5%and 96.3%, respectively. There was no significant difference in graft and patient survival between patients who received organs from infected donors and noninfected donors. CONCLUSION: Using organs from donors with bacteremia seems to be a safe option with low transmission risk. The overall prognosis of using organs from donors with BSI is favorable.
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spelling pubmed-87238932022-01-11 Kidney Transplantation From Deceased Donors With Bloodstream Infection: A Multicenter Retrospective Study Mo, Hyejin Lee, Juhan Park, Jae Berm Park, Sun Cheol Kim, Young Hoon Han, Ahram Jung, In Mok Ha, Jongwon Kim, Nam-Joong Min, Sangil J Korean Med Sci Original Article BACKGROUND: The use of organs from donors with infection is limited because of the possibility of transmission. We aimed to investigate the transmission after deceased donor transplantation with bloodstream infection (BSI). METHODS: A retrospective study of patients undergoing kidney or pancreas transplantation at five tertiary centers in Korea from January 2009 and November 2019 was performed. We analyzed the outcomes after transplantation from deceased donors with BSI. RESULTS: Eighty-six recipients received transplantation from 69 donors with BSI. The most common isolated pathogens from donors were Gram-positive bacteria (72.0%), followed by Gram-negative bacteria (22.7%), and fungi (5.3%). Appropriate antimicrobial agents were used in 47.8% of donors before transplantation. Transmission occurred only in 1 of 83 recipients (1.2%) from bacteremic donors and 1 of 6 recipients (16.7%) from fungemic donors. One-year patient and graft survival was 97.5%and 96.3%, respectively. There was no significant difference in graft and patient survival between patients who received organs from infected donors and noninfected donors. CONCLUSION: Using organs from donors with bacteremia seems to be a safe option with low transmission risk. The overall prognosis of using organs from donors with BSI is favorable. The Korean Academy of Medical Sciences 2021-11-29 /pmc/articles/PMC8723893/ /pubmed/34981680 http://dx.doi.org/10.3346/jkms.2022.37.e4 Text en © 2022 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mo, Hyejin
Lee, Juhan
Park, Jae Berm
Park, Sun Cheol
Kim, Young Hoon
Han, Ahram
Jung, In Mok
Ha, Jongwon
Kim, Nam-Joong
Min, Sangil
Kidney Transplantation From Deceased Donors With Bloodstream Infection: A Multicenter Retrospective Study
title Kidney Transplantation From Deceased Donors With Bloodstream Infection: A Multicenter Retrospective Study
title_full Kidney Transplantation From Deceased Donors With Bloodstream Infection: A Multicenter Retrospective Study
title_fullStr Kidney Transplantation From Deceased Donors With Bloodstream Infection: A Multicenter Retrospective Study
title_full_unstemmed Kidney Transplantation From Deceased Donors With Bloodstream Infection: A Multicenter Retrospective Study
title_short Kidney Transplantation From Deceased Donors With Bloodstream Infection: A Multicenter Retrospective Study
title_sort kidney transplantation from deceased donors with bloodstream infection: a multicenter retrospective study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723893/
https://www.ncbi.nlm.nih.gov/pubmed/34981680
http://dx.doi.org/10.3346/jkms.2022.37.e4
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