CD38 – Negative Anaplastic Plasma Cell Myeloma: A Rare Case Report

CD38 is a glycoprotein that is highly and uniformly expressed in plasma cells in multiple myeloma. A panel of CD38 and CD138/CD19/CD45/CD56/CD117 markers is considered the immunophenotypic diagnosis of plasma cell myeloma. Expression of the CD38 marker may fade or weaken compared with the CD138 mark...

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Detalles Bibliográficos
Autores principales: Thi Vinh Do, An, Lan Anh, Le
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723977/
https://www.ncbi.nlm.nih.gov/pubmed/35004078
http://dx.doi.org/10.7759/cureus.20909
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author Thi Vinh Do, An
Lan Anh, Le
author_facet Thi Vinh Do, An
Lan Anh, Le
author_sort Thi Vinh Do, An
collection PubMed
description CD38 is a glycoprotein that is highly and uniformly expressed in plasma cells in multiple myeloma. A panel of CD38 and CD138/CD19/CD45/CD56/CD117 markers is considered the immunophenotypic diagnosis of plasma cell myeloma. Expression of the CD38 marker may fade or weaken compared with the CD138 marker in plasma cells after chemotherapy treatment. Herein we present a rare case of CD38-negative multiple myeloma that was initially misdiagnosed as acute leukemia.
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spelling pubmed-87239772022-01-06 CD38 – Negative Anaplastic Plasma Cell Myeloma: A Rare Case Report Thi Vinh Do, An Lan Anh, Le Cureus Pathology CD38 is a glycoprotein that is highly and uniformly expressed in plasma cells in multiple myeloma. A panel of CD38 and CD138/CD19/CD45/CD56/CD117 markers is considered the immunophenotypic diagnosis of plasma cell myeloma. Expression of the CD38 marker may fade or weaken compared with the CD138 marker in plasma cells after chemotherapy treatment. Herein we present a rare case of CD38-negative multiple myeloma that was initially misdiagnosed as acute leukemia. Cureus 2022-01-03 /pmc/articles/PMC8723977/ /pubmed/35004078 http://dx.doi.org/10.7759/cureus.20909 Text en Copyright © 2022, Thi Vinh Do et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Thi Vinh Do, An
Lan Anh, Le
CD38 – Negative Anaplastic Plasma Cell Myeloma: A Rare Case Report
title CD38 – Negative Anaplastic Plasma Cell Myeloma: A Rare Case Report
title_full CD38 – Negative Anaplastic Plasma Cell Myeloma: A Rare Case Report
title_fullStr CD38 – Negative Anaplastic Plasma Cell Myeloma: A Rare Case Report
title_full_unstemmed CD38 – Negative Anaplastic Plasma Cell Myeloma: A Rare Case Report
title_short CD38 – Negative Anaplastic Plasma Cell Myeloma: A Rare Case Report
title_sort cd38 – negative anaplastic plasma cell myeloma: a rare case report
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723977/
https://www.ncbi.nlm.nih.gov/pubmed/35004078
http://dx.doi.org/10.7759/cureus.20909
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