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Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances

Kidney disease is becoming a global public health issue. Acute kidney injury (AKI) and chronic kidney disease (CKD) have serious adverse health outcomes. However, there is no effective therapy to treat these diseases. Lactoferrin (LF), a multi-functional glycoprotein, is protective against various p...

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Autores principales: Zahan, Md. Sarwar, Ahmed, Kazi Ahsan, Moni, Akhi, Sinopoli, Alessandra, Ha, Hunjoo, Uddin, Md Jamal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723984/
https://www.ncbi.nlm.nih.gov/pubmed/34965991
http://dx.doi.org/10.4196/kjpp.2022.26.1.1
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author Zahan, Md. Sarwar
Ahmed, Kazi Ahsan
Moni, Akhi
Sinopoli, Alessandra
Ha, Hunjoo
Uddin, Md Jamal
author_facet Zahan, Md. Sarwar
Ahmed, Kazi Ahsan
Moni, Akhi
Sinopoli, Alessandra
Ha, Hunjoo
Uddin, Md Jamal
author_sort Zahan, Md. Sarwar
collection PubMed
description Kidney disease is becoming a global public health issue. Acute kidney injury (AKI) and chronic kidney disease (CKD) have serious adverse health outcomes. However, there is no effective therapy to treat these diseases. Lactoferrin (LF), a multi-functional glycoprotein, is protective against various pathophysiological conditions in various disease models. LF shows protective effects against AKI and CKD. LF reduces markers related to inflammation, oxidative stress, apoptosis, and kidney fibrosis, and induces autophagy and mitochondrial biogenesis in the kidney. Although there are no clinical trials of LF to treat kidney disease, several clinical trials and studies on LF-based drug development are ongoing. In this review, we discussed the possible kidney protective mechanisms of LF, as well as the pharmacological and therapeutic advances. The evidence suggests that LF may become a potent pharmacological agent to treat kidney diseases.
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spelling pubmed-87239842022-01-11 Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances Zahan, Md. Sarwar Ahmed, Kazi Ahsan Moni, Akhi Sinopoli, Alessandra Ha, Hunjoo Uddin, Md Jamal Korean J Physiol Pharmacol Review Article Kidney disease is becoming a global public health issue. Acute kidney injury (AKI) and chronic kidney disease (CKD) have serious adverse health outcomes. However, there is no effective therapy to treat these diseases. Lactoferrin (LF), a multi-functional glycoprotein, is protective against various pathophysiological conditions in various disease models. LF shows protective effects against AKI and CKD. LF reduces markers related to inflammation, oxidative stress, apoptosis, and kidney fibrosis, and induces autophagy and mitochondrial biogenesis in the kidney. Although there are no clinical trials of LF to treat kidney disease, several clinical trials and studies on LF-based drug development are ongoing. In this review, we discussed the possible kidney protective mechanisms of LF, as well as the pharmacological and therapeutic advances. The evidence suggests that LF may become a potent pharmacological agent to treat kidney diseases. The Korean Physiological Society and The Korean Society of Pharmacology 2022-01-01 2022-01-01 /pmc/articles/PMC8723984/ /pubmed/34965991 http://dx.doi.org/10.4196/kjpp.2022.26.1.1 Text en Copyright © Korean J Physiol Pharmacol https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Zahan, Md. Sarwar
Ahmed, Kazi Ahsan
Moni, Akhi
Sinopoli, Alessandra
Ha, Hunjoo
Uddin, Md Jamal
Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
title Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
title_full Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
title_fullStr Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
title_full_unstemmed Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
title_short Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
title_sort kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723984/
https://www.ncbi.nlm.nih.gov/pubmed/34965991
http://dx.doi.org/10.4196/kjpp.2022.26.1.1
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