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Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances
Kidney disease is becoming a global public health issue. Acute kidney injury (AKI) and chronic kidney disease (CKD) have serious adverse health outcomes. However, there is no effective therapy to treat these diseases. Lactoferrin (LF), a multi-functional glycoprotein, is protective against various p...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Physiological Society and The Korean Society of Pharmacology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723984/ https://www.ncbi.nlm.nih.gov/pubmed/34965991 http://dx.doi.org/10.4196/kjpp.2022.26.1.1 |
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author | Zahan, Md. Sarwar Ahmed, Kazi Ahsan Moni, Akhi Sinopoli, Alessandra Ha, Hunjoo Uddin, Md Jamal |
author_facet | Zahan, Md. Sarwar Ahmed, Kazi Ahsan Moni, Akhi Sinopoli, Alessandra Ha, Hunjoo Uddin, Md Jamal |
author_sort | Zahan, Md. Sarwar |
collection | PubMed |
description | Kidney disease is becoming a global public health issue. Acute kidney injury (AKI) and chronic kidney disease (CKD) have serious adverse health outcomes. However, there is no effective therapy to treat these diseases. Lactoferrin (LF), a multi-functional glycoprotein, is protective against various pathophysiological conditions in various disease models. LF shows protective effects against AKI and CKD. LF reduces markers related to inflammation, oxidative stress, apoptosis, and kidney fibrosis, and induces autophagy and mitochondrial biogenesis in the kidney. Although there are no clinical trials of LF to treat kidney disease, several clinical trials and studies on LF-based drug development are ongoing. In this review, we discussed the possible kidney protective mechanisms of LF, as well as the pharmacological and therapeutic advances. The evidence suggests that LF may become a potent pharmacological agent to treat kidney diseases. |
format | Online Article Text |
id | pubmed-8723984 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Korean Physiological Society and The Korean Society of Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-87239842022-01-11 Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances Zahan, Md. Sarwar Ahmed, Kazi Ahsan Moni, Akhi Sinopoli, Alessandra Ha, Hunjoo Uddin, Md Jamal Korean J Physiol Pharmacol Review Article Kidney disease is becoming a global public health issue. Acute kidney injury (AKI) and chronic kidney disease (CKD) have serious adverse health outcomes. However, there is no effective therapy to treat these diseases. Lactoferrin (LF), a multi-functional glycoprotein, is protective against various pathophysiological conditions in various disease models. LF shows protective effects against AKI and CKD. LF reduces markers related to inflammation, oxidative stress, apoptosis, and kidney fibrosis, and induces autophagy and mitochondrial biogenesis in the kidney. Although there are no clinical trials of LF to treat kidney disease, several clinical trials and studies on LF-based drug development are ongoing. In this review, we discussed the possible kidney protective mechanisms of LF, as well as the pharmacological and therapeutic advances. The evidence suggests that LF may become a potent pharmacological agent to treat kidney diseases. The Korean Physiological Society and The Korean Society of Pharmacology 2022-01-01 2022-01-01 /pmc/articles/PMC8723984/ /pubmed/34965991 http://dx.doi.org/10.4196/kjpp.2022.26.1.1 Text en Copyright © Korean J Physiol Pharmacol https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zahan, Md. Sarwar Ahmed, Kazi Ahsan Moni, Akhi Sinopoli, Alessandra Ha, Hunjoo Uddin, Md Jamal Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances |
title | Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances |
title_full | Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances |
title_fullStr | Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances |
title_full_unstemmed | Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances |
title_short | Kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances |
title_sort | kidney protective potential of lactoferrin: pharmacological insights and therapeutic advances |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8723984/ https://www.ncbi.nlm.nih.gov/pubmed/34965991 http://dx.doi.org/10.4196/kjpp.2022.26.1.1 |
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