The Role of Heparin and Glycocalyx in Blood–Brain Barrier Dysfunction

The blood-brain barrier (BBB) functions as a dynamic boundary that protects the central nervous system from blood and plays an important role in maintaining the homeostasis of the brain. Dysfunction of the BBB is a pathophysiological characteristic of multiple neurologic diseases. Glycocalyx covers...

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Autores principales: Yang, Rui, Chen, Mingming, Zheng, Jiayin, Li, Xin, Zhang, Xiaojuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724024/
https://www.ncbi.nlm.nih.gov/pubmed/34992593
http://dx.doi.org/10.3389/fimmu.2021.754141
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author Yang, Rui
Chen, Mingming
Zheng, Jiayin
Li, Xin
Zhang, Xiaojuan
author_facet Yang, Rui
Chen, Mingming
Zheng, Jiayin
Li, Xin
Zhang, Xiaojuan
author_sort Yang, Rui
collection PubMed
description The blood-brain barrier (BBB) functions as a dynamic boundary that protects the central nervous system from blood and plays an important role in maintaining the homeostasis of the brain. Dysfunction of the BBB is a pathophysiological characteristic of multiple neurologic diseases. Glycocalyx covers the luminal side of vascular endothelial cells(ECs). Damage of glycocalyx leads to disruption of the BBB, while inhibiting glycocalyx degradation maintains BBB integrity. Heparin has been recognized as an anticoagulant and it protects endothelial glycocalyx from destruction. In this review, we summarize the role of glycocalyx in BBB formation and the therapeutic potency of heparin to provide a theoretical basis for the treatment of neurological diseases related to BBB breakdown.
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spelling pubmed-87240242022-01-05 The Role of Heparin and Glycocalyx in Blood–Brain Barrier Dysfunction Yang, Rui Chen, Mingming Zheng, Jiayin Li, Xin Zhang, Xiaojuan Front Immunol Immunology The blood-brain barrier (BBB) functions as a dynamic boundary that protects the central nervous system from blood and plays an important role in maintaining the homeostasis of the brain. Dysfunction of the BBB is a pathophysiological characteristic of multiple neurologic diseases. Glycocalyx covers the luminal side of vascular endothelial cells(ECs). Damage of glycocalyx leads to disruption of the BBB, while inhibiting glycocalyx degradation maintains BBB integrity. Heparin has been recognized as an anticoagulant and it protects endothelial glycocalyx from destruction. In this review, we summarize the role of glycocalyx in BBB formation and the therapeutic potency of heparin to provide a theoretical basis for the treatment of neurological diseases related to BBB breakdown. Frontiers Media S.A. 2021-12-21 /pmc/articles/PMC8724024/ /pubmed/34992593 http://dx.doi.org/10.3389/fimmu.2021.754141 Text en Copyright © 2021 Yang, Chen, Zheng, Li and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yang, Rui
Chen, Mingming
Zheng, Jiayin
Li, Xin
Zhang, Xiaojuan
The Role of Heparin and Glycocalyx in Blood–Brain Barrier Dysfunction
title The Role of Heparin and Glycocalyx in Blood–Brain Barrier Dysfunction
title_full The Role of Heparin and Glycocalyx in Blood–Brain Barrier Dysfunction
title_fullStr The Role of Heparin and Glycocalyx in Blood–Brain Barrier Dysfunction
title_full_unstemmed The Role of Heparin and Glycocalyx in Blood–Brain Barrier Dysfunction
title_short The Role of Heparin and Glycocalyx in Blood–Brain Barrier Dysfunction
title_sort role of heparin and glycocalyx in blood–brain barrier dysfunction
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724024/
https://www.ncbi.nlm.nih.gov/pubmed/34992593
http://dx.doi.org/10.3389/fimmu.2021.754141
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