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Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis
OBJECTIVE: Hepatitis C virus (HCV) causes neuropsychiatric disorders and quality of life impairment, especially in patients with cryoglobulinemic vasculitis (CV). Direct acting antivirals (DAAs) are effective in most extrahepatic HCV diseases, but limited information exists regarding the outcome of...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724104/ https://www.ncbi.nlm.nih.gov/pubmed/34409558 http://dx.doi.org/10.1007/s10067-021-05877-3 |
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author | Gragnani, Laura Lorini, Serena Martini, Lorenzo Stasi, Cristina Visentini, Marcella Petraccia, Luisa Marello, Niccolò Monti, Monica Marri, Silvia Madia, Francesco Ricca, Valdo Zignego, Anna Linda |
author_facet | Gragnani, Laura Lorini, Serena Martini, Lorenzo Stasi, Cristina Visentini, Marcella Petraccia, Luisa Marello, Niccolò Monti, Monica Marri, Silvia Madia, Francesco Ricca, Valdo Zignego, Anna Linda |
author_sort | Gragnani, Laura |
collection | PubMed |
description | OBJECTIVE: Hepatitis C virus (HCV) causes neuropsychiatric disorders and quality of life impairment, especially in patients with cryoglobulinemic vasculitis (CV). Direct acting antivirals (DAAs) are effective in most extrahepatic HCV diseases, but limited information exists regarding the outcome of psychiatric disorders in patients with and without CV, after therapy. We aimed to evaluate psychiatric outcomes, in HCV-patients with and without CV, before and after successful DAA therapy. METHODS: We prospectively studied DAA-treated HCV-patients, stratified into presence (CV) or absence of CV (NON-CV). Four psychometric scales were administered to assess depression (HAM-D and MADRS), anxiety (HAM-A), and mania (MRS). Short-Form-36 questionnaires evaluated quality of life. RESULTS: Seventy-six patients were recruited, and 47 CV and 29 NON-CV were treated with antivirals. At baseline, depression and anxiety, from mild to severe, were frequently shown, with the most advanced cases in thee CV group; no patients achieved the scores for mania. A significant improvement emerged for all the psychometric scales in the entire population and in the subgroups, after viral eradication even in the short-term outcome. The Short-Form-36 summary components showed benefits. CONCLUSIONS: After HCV eradication, the depression and anxiety scores significantly improved and severity grade generally lowered. DAA-positive effects on mental disorders should be considered part of the therapy outcome, being beneficial especially in CV patients who usually have worse baseline mental scores. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10067-021-05877-3. |
format | Online Article Text |
id | pubmed-8724104 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-87241042022-01-13 Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis Gragnani, Laura Lorini, Serena Martini, Lorenzo Stasi, Cristina Visentini, Marcella Petraccia, Luisa Marello, Niccolò Monti, Monica Marri, Silvia Madia, Francesco Ricca, Valdo Zignego, Anna Linda Clin Rheumatol Original Article OBJECTIVE: Hepatitis C virus (HCV) causes neuropsychiatric disorders and quality of life impairment, especially in patients with cryoglobulinemic vasculitis (CV). Direct acting antivirals (DAAs) are effective in most extrahepatic HCV diseases, but limited information exists regarding the outcome of psychiatric disorders in patients with and without CV, after therapy. We aimed to evaluate psychiatric outcomes, in HCV-patients with and without CV, before and after successful DAA therapy. METHODS: We prospectively studied DAA-treated HCV-patients, stratified into presence (CV) or absence of CV (NON-CV). Four psychometric scales were administered to assess depression (HAM-D and MADRS), anxiety (HAM-A), and mania (MRS). Short-Form-36 questionnaires evaluated quality of life. RESULTS: Seventy-six patients were recruited, and 47 CV and 29 NON-CV were treated with antivirals. At baseline, depression and anxiety, from mild to severe, were frequently shown, with the most advanced cases in thee CV group; no patients achieved the scores for mania. A significant improvement emerged for all the psychometric scales in the entire population and in the subgroups, after viral eradication even in the short-term outcome. The Short-Form-36 summary components showed benefits. CONCLUSIONS: After HCV eradication, the depression and anxiety scores significantly improved and severity grade generally lowered. DAA-positive effects on mental disorders should be considered part of the therapy outcome, being beneficial especially in CV patients who usually have worse baseline mental scores. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10067-021-05877-3. Springer International Publishing 2021-08-19 2022 /pmc/articles/PMC8724104/ /pubmed/34409558 http://dx.doi.org/10.1007/s10067-021-05877-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Article Gragnani, Laura Lorini, Serena Martini, Lorenzo Stasi, Cristina Visentini, Marcella Petraccia, Luisa Marello, Niccolò Monti, Monica Marri, Silvia Madia, Francesco Ricca, Valdo Zignego, Anna Linda Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis |
title | Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis |
title_full | Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis |
title_fullStr | Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis |
title_full_unstemmed | Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis |
title_short | Rapid improvement of psychiatric stigmata after IFN-free treatment in HCV patients with and without cryoglobulinemic vasculitis |
title_sort | rapid improvement of psychiatric stigmata after ifn-free treatment in hcv patients with and without cryoglobulinemic vasculitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724104/ https://www.ncbi.nlm.nih.gov/pubmed/34409558 http://dx.doi.org/10.1007/s10067-021-05877-3 |
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