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Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers

Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields. Recent developments in chemical and biological researches have drawn much attention to the measurement of substances with low abundances in samples. Continuous efforts have been made consequently to further i...

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Autores principales: Li, Chang, Chu, Shiying, Tan, Siyuan, Yin, Xinchi, Jiang, You, Dai, Xinhua, Gong, Xiaoyun, Fang, Xiang, Tian, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724130/
https://www.ncbi.nlm.nih.gov/pubmed/34993180
http://dx.doi.org/10.3389/fchem.2021.813359
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author Li, Chang
Chu, Shiying
Tan, Siyuan
Yin, Xinchi
Jiang, You
Dai, Xinhua
Gong, Xiaoyun
Fang, Xiang
Tian, Di
author_facet Li, Chang
Chu, Shiying
Tan, Siyuan
Yin, Xinchi
Jiang, You
Dai, Xinhua
Gong, Xiaoyun
Fang, Xiang
Tian, Di
author_sort Li, Chang
collection PubMed
description Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields. Recent developments in chemical and biological researches have drawn much attention to the measurement of substances with low abundances in samples. Continuous efforts have been made consequently to further improve the sensitivity of MS. Modifications on the mass analyzers of mass spectrometers offer a direct, universal and practical way to obtain higher sensitivity. This review provides a comprehensive overview of the latest developments in mass analyzers for the improvement of mass spectrometers’ sensitivity, including quadrupole, ion trap, time-of-flight (TOF) and Fourier transform ion cyclotron (FT-ICR), as well as different combinations of these mass analyzers. The advantages and limitations of different mass analyzers and their combinations are compared and discussed. This review provides guidance to the selection of suitable mass spectrometers in chemical and biological analytical applications. It is also beneficial to the development of novel mass spectrometers.
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spelling pubmed-87241302022-01-05 Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers Li, Chang Chu, Shiying Tan, Siyuan Yin, Xinchi Jiang, You Dai, Xinhua Gong, Xiaoyun Fang, Xiang Tian, Di Front Chem Chemistry Mass spectrometry (MS) is one of the most widely used analytical techniques in many fields. Recent developments in chemical and biological researches have drawn much attention to the measurement of substances with low abundances in samples. Continuous efforts have been made consequently to further improve the sensitivity of MS. Modifications on the mass analyzers of mass spectrometers offer a direct, universal and practical way to obtain higher sensitivity. This review provides a comprehensive overview of the latest developments in mass analyzers for the improvement of mass spectrometers’ sensitivity, including quadrupole, ion trap, time-of-flight (TOF) and Fourier transform ion cyclotron (FT-ICR), as well as different combinations of these mass analyzers. The advantages and limitations of different mass analyzers and their combinations are compared and discussed. This review provides guidance to the selection of suitable mass spectrometers in chemical and biological analytical applications. It is also beneficial to the development of novel mass spectrometers. Frontiers Media S.A. 2021-12-21 /pmc/articles/PMC8724130/ /pubmed/34993180 http://dx.doi.org/10.3389/fchem.2021.813359 Text en Copyright © 2021 Li, Chu, Tan, Yin, Jiang, Dai, Gong, Fang and Tian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Li, Chang
Chu, Shiying
Tan, Siyuan
Yin, Xinchi
Jiang, You
Dai, Xinhua
Gong, Xiaoyun
Fang, Xiang
Tian, Di
Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers
title Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers
title_full Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers
title_fullStr Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers
title_full_unstemmed Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers
title_short Towards Higher Sensitivity of Mass Spectrometry: A Perspective From the Mass Analyzers
title_sort towards higher sensitivity of mass spectrometry: a perspective from the mass analyzers
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724130/
https://www.ncbi.nlm.nih.gov/pubmed/34993180
http://dx.doi.org/10.3389/fchem.2021.813359
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