Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewe...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Jiaqi, Xiao, Qing, Xiao, Jiani, Niu, Chenxi, Li, Yuanyuan, Zhang, Xiaojun, Zhou, Zhengwei, Shu, Guang, Yin, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724284/
https://www.ncbi.nlm.nih.gov/pubmed/34980884
http://dx.doi.org/10.1038/s41392-021-00762-6
_version_ 1784625891641393152
author Liu, Jiaqi
Xiao, Qing
Xiao, Jiani
Niu, Chenxi
Li, Yuanyuan
Zhang, Xiaojun
Zhou, Zhengwei
Shu, Guang
Yin, Gang
author_facet Liu, Jiaqi
Xiao, Qing
Xiao, Jiani
Niu, Chenxi
Li, Yuanyuan
Zhang, Xiaojun
Zhou, Zhengwei
Shu, Guang
Yin, Gang
author_sort Liu, Jiaqi
collection PubMed
description The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.
format Online
Article
Text
id pubmed-8724284
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-87242842022-01-18 Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities Liu, Jiaqi Xiao, Qing Xiao, Jiani Niu, Chenxi Li, Yuanyuan Zhang, Xiaojun Zhou, Zhengwei Shu, Guang Yin, Gang Signal Transduct Target Ther Review Article The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment. Nature Publishing Group UK 2022-01-03 /pmc/articles/PMC8724284/ /pubmed/34980884 http://dx.doi.org/10.1038/s41392-021-00762-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Liu, Jiaqi
Xiao, Qing
Xiao, Jiani
Niu, Chenxi
Li, Yuanyuan
Zhang, Xiaojun
Zhou, Zhengwei
Shu, Guang
Yin, Gang
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
title Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
title_full Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
title_fullStr Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
title_full_unstemmed Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
title_short Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
title_sort wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724284/
https://www.ncbi.nlm.nih.gov/pubmed/34980884
http://dx.doi.org/10.1038/s41392-021-00762-6
work_keys_str_mv AT liujiaqi wntbcateninsignallingfunctionbiologicalmechanismsandtherapeuticopportunities
AT xiaoqing wntbcateninsignallingfunctionbiologicalmechanismsandtherapeuticopportunities
AT xiaojiani wntbcateninsignallingfunctionbiologicalmechanismsandtherapeuticopportunities
AT niuchenxi wntbcateninsignallingfunctionbiologicalmechanismsandtherapeuticopportunities
AT liyuanyuan wntbcateninsignallingfunctionbiologicalmechanismsandtherapeuticopportunities
AT zhangxiaojun wntbcateninsignallingfunctionbiologicalmechanismsandtherapeuticopportunities
AT zhouzhengwei wntbcateninsignallingfunctionbiologicalmechanismsandtherapeuticopportunities
AT shuguang wntbcateninsignallingfunctionbiologicalmechanismsandtherapeuticopportunities
AT yingang wntbcateninsignallingfunctionbiologicalmechanismsandtherapeuticopportunities

Ejemplares similares