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The epigenetic landscape of exercise in cardiac health and disease

With the rising incidence of cardiovascular diseases, the concomitant mortality and morbidity impose huge burdens on quality of life and societal costs. It is generally accepted that physical inactivity is one of the major risk factors for cardiac disease and that exercise benefits the heart in both...

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Detalles Bibliográficos
Autores principales: Wu, Guiling, Zhang, Xing, Gao, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shanghai University of Sport 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724625/
https://www.ncbi.nlm.nih.gov/pubmed/33333247
http://dx.doi.org/10.1016/j.jshs.2020.12.003
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author Wu, Guiling
Zhang, Xing
Gao, Feng
author_facet Wu, Guiling
Zhang, Xing
Gao, Feng
author_sort Wu, Guiling
collection PubMed
description With the rising incidence of cardiovascular diseases, the concomitant mortality and morbidity impose huge burdens on quality of life and societal costs. It is generally accepted that physical inactivity is one of the major risk factors for cardiac disease and that exercise benefits the heart in both physiological and pathologic conditions. However, the molecular mechanisms governing the cardioprotective effects exerted by exercise remain incompletely understood. Most recently, an increasing number of studies indicate the involvement of epigenetic modifications in the promotion of cardiac health and prevention of cardiac disease. Exercise and other lifestyle factors extensively induce epigenetic modifications, including DNA/RNA methylation, histone post-translational modifications, and non-coding RNAs in multiple tissues, which may contribute to their positive effects in human health and diseases. In addition, several studies have shown that maternal or paternal exercise prevents age-associated or high-fat diet-induced metabolic dysfunction in the offspring, reinforcing the importance of epigenetics in mediating the beneficial effects of exercise. It has been shown that exercise can directly modify cardiac epigenetics to promote cardiac health and protect the heart against various pathological processes, or it can modify epigenetics in other tissues, which reduces the risk of cardiac disease and affords cardioprotection through exerkines. An in-depth understanding of the epigenetic landscape of cardioprotective response to exercise will provide new therapeutic targets for cardiac diseases. This review, therefore, aimed to acquaint the cardiac community with the rapidly advancing and evolving field of exercise and epigenetics.
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spelling pubmed-87246252022-01-11 The epigenetic landscape of exercise in cardiac health and disease Wu, Guiling Zhang, Xing Gao, Feng J Sport Health Sci Review With the rising incidence of cardiovascular diseases, the concomitant mortality and morbidity impose huge burdens on quality of life and societal costs. It is generally accepted that physical inactivity is one of the major risk factors for cardiac disease and that exercise benefits the heart in both physiological and pathologic conditions. However, the molecular mechanisms governing the cardioprotective effects exerted by exercise remain incompletely understood. Most recently, an increasing number of studies indicate the involvement of epigenetic modifications in the promotion of cardiac health and prevention of cardiac disease. Exercise and other lifestyle factors extensively induce epigenetic modifications, including DNA/RNA methylation, histone post-translational modifications, and non-coding RNAs in multiple tissues, which may contribute to their positive effects in human health and diseases. In addition, several studies have shown that maternal or paternal exercise prevents age-associated or high-fat diet-induced metabolic dysfunction in the offspring, reinforcing the importance of epigenetics in mediating the beneficial effects of exercise. It has been shown that exercise can directly modify cardiac epigenetics to promote cardiac health and protect the heart against various pathological processes, or it can modify epigenetics in other tissues, which reduces the risk of cardiac disease and affords cardioprotection through exerkines. An in-depth understanding of the epigenetic landscape of cardioprotective response to exercise will provide new therapeutic targets for cardiac diseases. This review, therefore, aimed to acquaint the cardiac community with the rapidly advancing and evolving field of exercise and epigenetics. Shanghai University of Sport 2021-12 2020-12-14 /pmc/articles/PMC8724625/ /pubmed/33333247 http://dx.doi.org/10.1016/j.jshs.2020.12.003 Text en © 2021 Published by Elsevier B.V. on behalf of Shanghai University of Sport. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Wu, Guiling
Zhang, Xing
Gao, Feng
The epigenetic landscape of exercise in cardiac health and disease
title The epigenetic landscape of exercise in cardiac health and disease
title_full The epigenetic landscape of exercise in cardiac health and disease
title_fullStr The epigenetic landscape of exercise in cardiac health and disease
title_full_unstemmed The epigenetic landscape of exercise in cardiac health and disease
title_short The epigenetic landscape of exercise in cardiac health and disease
title_sort epigenetic landscape of exercise in cardiac health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724625/
https://www.ncbi.nlm.nih.gov/pubmed/33333247
http://dx.doi.org/10.1016/j.jshs.2020.12.003
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