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Estimands: bringing clarity and focus to research questions in clinical trials

Precise specification of the research question and associated treatment effect of interest is essential in clinical research, yet recent work shows that they are often incompletely specified. The ICH E9 (R1) Addendum on Estimands and Sensitivity Analysis in Clinical Trials introduces a framework tha...

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Detalles Bibliográficos
Autores principales:	Clark, Timothy Peter, Kahan, Brennan C, Phillips, Alan, White, Ian, Carpenter, James R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Research Methods
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724703/ https://www.ncbi.nlm.nih.gov/pubmed/34980616 http://dx.doi.org/10.1136/bmjopen-2021-052953

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