The epitope arrangement on flavivirus particles contributes to Mab C10’s extraordinary neutralization breadth across Zika and dengue viruses

The human monoclonal antibody C10 exhibits extraordinary cross-reactivity, potently neutralizing Zika virus (ZIKV) and the four serotypes of dengue virus (DENV1–DENV4). Here we describe a comparative structure-function analysis of C10 bound to the envelope (E) protein dimers of the five viruses it n...

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Detalles Bibliográficos
Autores principales: Sharma, Arvind, Zhang, Xiaokang, Dejnirattisai, Wanwisa, Dai, Xinghong, Gong, Danyang, Wongwiwat, Wiyada, Duquerroy, Stéphane, Rouvinski, Alexander, Vaney, Marie-Christine, Guardado-Calvo, Pablo, Haouz, Ahmed, England, Patrick, Sun, Ren, Zhou, Z. Hong, Mongkolsapaya, Juthathip, Screaton, Gavin R., Rey, Felix A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724787/
https://www.ncbi.nlm.nih.gov/pubmed/34852239
http://dx.doi.org/10.1016/j.cell.2021.11.010

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