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Olfactory and Gustatory Dysfunction in 2019 Novel Coronavirus: An Updated Systematic Review and Meta-analysis

BACKGROUND: Evidence showed that partial or complete loss of smell and taste might be a possible primary symptom of the 2019 novel coronavirus (COVID-19). This study aimed to systematically review and pool all available evidence on the olfactory and gustatory dysfunction in COVID-19 patients. METHOD...

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Autores principales: Esmaeili, Marzieh, Abdi, Fatemeh, Shafiee, Gita, Asayesh, Hamid, Abdar, Zahra Esmaeili, Baygi, Fereshteh, Qorbani, Mostafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724794/
https://www.ncbi.nlm.nih.gov/pubmed/35070203
http://dx.doi.org/10.4103/ijpvm.IJPVM_484_20
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author Esmaeili, Marzieh
Abdi, Fatemeh
Shafiee, Gita
Asayesh, Hamid
Abdar, Zahra Esmaeili
Baygi, Fereshteh
Qorbani, Mostafa
author_facet Esmaeili, Marzieh
Abdi, Fatemeh
Shafiee, Gita
Asayesh, Hamid
Abdar, Zahra Esmaeili
Baygi, Fereshteh
Qorbani, Mostafa
author_sort Esmaeili, Marzieh
collection PubMed
description BACKGROUND: Evidence showed that partial or complete loss of smell and taste might be a possible primary symptom of the 2019 novel coronavirus (COVID-19). This study aimed to systematically review and pool all available evidence on the olfactory and gustatory dysfunction in COVID-19 patients. METHODS: In this systematic review, a comprehensive search was carried out systematically through e-databases including PubMed, EMBASE, Scopus, and Web of Science (WoS); that was limited to English-language studies published from 2019 up to 6(th) May 2020. Afterward, all studies reported the taste and smell dysfunction in the COVID-19 patients were included. The quality of the studies was assessed by the Mixed Methods Appraisal Tool (MMAT). The pooled prevalence of olfactory and gustatory dysfunction was estimated using the random effects meta-analysis method. RESULTS: Among 28 eligible included studies in this systematic review, finally, 22 studies met the eligibility criteria and were included in the meta-analysis. According to the random effect meta-analysis, the global pooled prevalence (95% confidence interval) of any olfactory dysfunction, anosmia, and hyposmia was 55% (40%-70%), 40% (22%-57%), and 40% (20%-61%) respectively. The pooled estimated prevalence of any gustatory dysfunction, ageusia, and dysgeusia was 41% (23%-59%), 31% (3%-59%), and 34% (19%-48%) respectively. CONCLUSIONS: Olfactory and gustatory dysfunction is prevalent among COVID-19 patients. Therefore, olfactory and gustatory dysfunction seems to be part of important symptoms and notify for the diagnosis of COVID-19, especially in the early phase of the infection.
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spelling pubmed-87247942022-01-20 Olfactory and Gustatory Dysfunction in 2019 Novel Coronavirus: An Updated Systematic Review and Meta-analysis Esmaeili, Marzieh Abdi, Fatemeh Shafiee, Gita Asayesh, Hamid Abdar, Zahra Esmaeili Baygi, Fereshteh Qorbani, Mostafa Int J Prev Med Review Article BACKGROUND: Evidence showed that partial or complete loss of smell and taste might be a possible primary symptom of the 2019 novel coronavirus (COVID-19). This study aimed to systematically review and pool all available evidence on the olfactory and gustatory dysfunction in COVID-19 patients. METHODS: In this systematic review, a comprehensive search was carried out systematically through e-databases including PubMed, EMBASE, Scopus, and Web of Science (WoS); that was limited to English-language studies published from 2019 up to 6(th) May 2020. Afterward, all studies reported the taste and smell dysfunction in the COVID-19 patients were included. The quality of the studies was assessed by the Mixed Methods Appraisal Tool (MMAT). The pooled prevalence of olfactory and gustatory dysfunction was estimated using the random effects meta-analysis method. RESULTS: Among 28 eligible included studies in this systematic review, finally, 22 studies met the eligibility criteria and were included in the meta-analysis. According to the random effect meta-analysis, the global pooled prevalence (95% confidence interval) of any olfactory dysfunction, anosmia, and hyposmia was 55% (40%-70%), 40% (22%-57%), and 40% (20%-61%) respectively. The pooled estimated prevalence of any gustatory dysfunction, ageusia, and dysgeusia was 41% (23%-59%), 31% (3%-59%), and 34% (19%-48%) respectively. CONCLUSIONS: Olfactory and gustatory dysfunction is prevalent among COVID-19 patients. Therefore, olfactory and gustatory dysfunction seems to be part of important symptoms and notify for the diagnosis of COVID-19, especially in the early phase of the infection. Wolters Kluwer - Medknow 2021-12-14 /pmc/articles/PMC8724794/ /pubmed/35070203 http://dx.doi.org/10.4103/ijpvm.IJPVM_484_20 Text en Copyright: © 2021 International Journal of Preventive Medicine https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Esmaeili, Marzieh
Abdi, Fatemeh
Shafiee, Gita
Asayesh, Hamid
Abdar, Zahra Esmaeili
Baygi, Fereshteh
Qorbani, Mostafa
Olfactory and Gustatory Dysfunction in 2019 Novel Coronavirus: An Updated Systematic Review and Meta-analysis
title Olfactory and Gustatory Dysfunction in 2019 Novel Coronavirus: An Updated Systematic Review and Meta-analysis
title_full Olfactory and Gustatory Dysfunction in 2019 Novel Coronavirus: An Updated Systematic Review and Meta-analysis
title_fullStr Olfactory and Gustatory Dysfunction in 2019 Novel Coronavirus: An Updated Systematic Review and Meta-analysis
title_full_unstemmed Olfactory and Gustatory Dysfunction in 2019 Novel Coronavirus: An Updated Systematic Review and Meta-analysis
title_short Olfactory and Gustatory Dysfunction in 2019 Novel Coronavirus: An Updated Systematic Review and Meta-analysis
title_sort olfactory and gustatory dysfunction in 2019 novel coronavirus: an updated systematic review and meta-analysis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724794/
https://www.ncbi.nlm.nih.gov/pubmed/35070203
http://dx.doi.org/10.4103/ijpvm.IJPVM_484_20
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