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Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair

Alternative lengthening of telomeres (ALT) is a telomere-elongation mechanism observed in ~15% of cancer subtypes. Current models indicate that ALT is mediated by homology-directed repair mechanisms. By disrupting MSH6 gene expression, we show that the deficiency of MutSα (MSH2/MSH6) DNA mismatch re...

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Detalles Bibliográficos
Autores principales:	Barroso-González, Jonathan, García-Expósito, Laura, Galaviz, Pablo, Lee Lynskey, Michelle, Allen, Joshua A.M., Hoang, SongMy, Watkins, Simon C., Pickett, Hilda A., O’Sullivan, Roderick J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724847/ https://www.ncbi.nlm.nih.gov/pubmed/34879271 http://dx.doi.org/10.1016/j.celrep.2021.110088

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