Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples

MS is the most effective method to directly identify peptides presented on human leukocyte antigen (HLA) molecules. However, current standard approaches often use 500 million or more cells as input to achieve high coverage of the immunopeptidome, and therefore, these methods are not compatible with...

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Detalles Bibliográficos
Autores principales: Klaeger, Susan, Apffel, Annie, Clauser, Karl R., Sarkizova, Siranush, Oliveira, Giacomo, Rachimi, Suzanna, Le, Phuong M., Tarren, Anna, Chea, Vipheaviny, Abelin, Jennifer G., Braun, David A., Ott, Patrick A., Keshishian, Hasmik, Hacohen, Nir, Keskin, Derin B., Wu, Catherine J., Carr, Steven A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Technological Innovation and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724927/
https://www.ncbi.nlm.nih.gov/pubmed/34391888
http://dx.doi.org/10.1016/j.mcpro.2021.100133

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