A case of long-term complete remission of locally advanced T4 bladder cancer treated with pembrolizumab

A 69-year-old man with a history of non-muscle invasive bladder cancer 12 years ago presented complaining of gross hematuria. He was diagnosed as having invasive T4 bladder cancer with invasion to a branch of the internal iliac artery and received platinum-based chemo-radiation therapy. However, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Horibe, Yuki, Nakata, Wataru, Tsujimura, Goh, Tsujimoto, Yuichi, Gotoh, Takayoshi, Tsujihata, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724930/
https://www.ncbi.nlm.nih.gov/pubmed/35024340
http://dx.doi.org/10.1016/j.eucr.2021.101959
_version_ 1784626008729583616
author Horibe, Yuki
Nakata, Wataru
Tsujimura, Goh
Tsujimoto, Yuichi
Gotoh, Takayoshi
Tsujihata, Masao
author_facet Horibe, Yuki
Nakata, Wataru
Tsujimura, Goh
Tsujimoto, Yuichi
Gotoh, Takayoshi
Tsujihata, Masao
author_sort Horibe, Yuki
collection PubMed
description A 69-year-old man with a history of non-muscle invasive bladder cancer 12 years ago presented complaining of gross hematuria. He was diagnosed as having invasive T4 bladder cancer with invasion to a branch of the internal iliac artery and received platinum-based chemo-radiation therapy. However, the tumor progressed to extensively infiltrate the pelvic wall, and left leg pain and swelling developed. Pembrolizumab was started, which entirely resolved the tumor after 14 courses of treatment. Pembrolizumab was discontinued after 20 courses of treatment because of adverse events. However, the patient has remained in complete response for over 2 years after pembrolizumab cessation.
format Online
Article
Text
id pubmed-8724930
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-87249302022-01-11 A case of long-term complete remission of locally advanced T4 bladder cancer treated with pembrolizumab Horibe, Yuki Nakata, Wataru Tsujimura, Goh Tsujimoto, Yuichi Gotoh, Takayoshi Tsujihata, Masao Urol Case Rep Oncology A 69-year-old man with a history of non-muscle invasive bladder cancer 12 years ago presented complaining of gross hematuria. He was diagnosed as having invasive T4 bladder cancer with invasion to a branch of the internal iliac artery and received platinum-based chemo-radiation therapy. However, the tumor progressed to extensively infiltrate the pelvic wall, and left leg pain and swelling developed. Pembrolizumab was started, which entirely resolved the tumor after 14 courses of treatment. Pembrolizumab was discontinued after 20 courses of treatment because of adverse events. However, the patient has remained in complete response for over 2 years after pembrolizumab cessation. Elsevier 2021-11-27 /pmc/articles/PMC8724930/ /pubmed/35024340 http://dx.doi.org/10.1016/j.eucr.2021.101959 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Oncology
Horibe, Yuki
Nakata, Wataru
Tsujimura, Goh
Tsujimoto, Yuichi
Gotoh, Takayoshi
Tsujihata, Masao
A case of long-term complete remission of locally advanced T4 bladder cancer treated with pembrolizumab
title A case of long-term complete remission of locally advanced T4 bladder cancer treated with pembrolizumab
title_full A case of long-term complete remission of locally advanced T4 bladder cancer treated with pembrolizumab
title_fullStr A case of long-term complete remission of locally advanced T4 bladder cancer treated with pembrolizumab
title_full_unstemmed A case of long-term complete remission of locally advanced T4 bladder cancer treated with pembrolizumab
title_short A case of long-term complete remission of locally advanced T4 bladder cancer treated with pembrolizumab
title_sort case of long-term complete remission of locally advanced t4 bladder cancer treated with pembrolizumab
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724930/
https://www.ncbi.nlm.nih.gov/pubmed/35024340
http://dx.doi.org/10.1016/j.eucr.2021.101959
work_keys_str_mv AT horibeyuki acaseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT nakatawataru acaseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT tsujimuragoh acaseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT tsujimotoyuichi acaseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT gotohtakayoshi acaseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT tsujihatamasao acaseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT horibeyuki caseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT nakatawataru caseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT tsujimuragoh caseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT tsujimotoyuichi caseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT gotohtakayoshi caseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab
AT tsujihatamasao caseoflongtermcompleteremissionoflocallyadvancedt4bladdercancertreatedwithpembrolizumab

Ejemplares similares