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A novel PAK4 inhibitor suppresses pancreatic cancer growth and enhances the inhibitory effect of gemcitabine

Over 95% of Pancreatic ductal adenocarcinomas (PDA) carry mutations in the oncogene KRas which has been proven to be a difficult drug target. P21-activated kinase 4 (PAK4), acts downstream of KRas, and is overexpressed in PDA contributing to its growth and chemoresistance, and thus becomes an attrac...

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Detalles Bibliográficos
Autores principales:	He, Hong, Dumesny, Chelsea, Ang, Ching-Seng, Dong, Li, Ma, Yi, Zeng, Jun, Nikfarjam, Mehrdad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724943/ https://www.ncbi.nlm.nih.gov/pubmed/34973571 http://dx.doi.org/10.1016/j.tranon.2021.101329

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