The effect of mAb and excipient cryoconcentration on long-term frozen storage stability – Part 1: Higher molecular weight species and subvisible particle formation

Cryoconcentration upon large-scale freezing of monoclonal antibody (mAb) solutions leads to regions of different ratios of low molecular weight excipients, like buffer species or sugars, to protein. This study focused on the impact of the buffer species to mAb ratio on aggregate formation after froz...

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Detalles Bibliográficos
Autores principales: Bluemel, Oliver, Anuschek, Moritz, Buecheler, Jakob W., Hoelzl, Georg, Bechtold-Peters, Karoline, Friess, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724966/
https://www.ncbi.nlm.nih.gov/pubmed/35024603
http://dx.doi.org/10.1016/j.ijpx.2021.100108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724966/
https://www.ncbi.nlm.nih.gov/pubmed/35024603
http://dx.doi.org/10.1016/j.ijpx.2021.100108

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