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Topical Capsaicin for the Treatment of Sensory Neuropathic Cough

OBJECTIVE: To evaluate a novel treatment for sensory neuropathic cough (SNC): topical capsaicin. STUDY DESIGN: Retrospective review. SETTING: Tertiary care laryngology clinic. METHODS: A retrospective review was performed on 201 consecutive patients treated for SNC with capsaicin 0.02% to 0.04% appl...

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Autores principales: Hoesli, Rebecca C., Wingo, Melissa L., Wajsberg, Benjamin, Bastian, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724998/
https://www.ncbi.nlm.nih.gov/pubmed/34993384
http://dx.doi.org/10.1177/2473974X211065668
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author Hoesli, Rebecca C.
Wingo, Melissa L.
Wajsberg, Benjamin
Bastian, Robert W.
author_facet Hoesli, Rebecca C.
Wingo, Melissa L.
Wajsberg, Benjamin
Bastian, Robert W.
author_sort Hoesli, Rebecca C.
collection PubMed
description OBJECTIVE: To evaluate a novel treatment for sensory neuropathic cough (SNC): topical capsaicin. STUDY DESIGN: Retrospective review. SETTING: Tertiary care laryngology clinic. METHODS: A retrospective review was performed on 201 consecutive patients treated for SNC with capsaicin 0.02% to 0.04% applied topically to the upper aerodigestive tract, typically after failure of standard medications. Patients were asked to use the spray 4 times daily for 2 weeks prior to assessment of benefit. Items assessed included the percentage reduction of coughing, type of benefit noted, and side effects. RESULTS: Of the 201 patients who used the spray, 36.3% noted no benefit, whereas 63.7% (n = 128) had benefit in terms of cough reduction: 30.8% (n = 62) reported ≥75% reduction; 17.4% (n = 35), 50%-74% reduction; 7.0% (n = 14), 25%-49% reduction; and 8.5% (n = 17), 1%-24% reduction. Of all patients, 78.3% reported no side effects or complications. Of the remaining 21.7%, 1 patient noted a nosebleed after a single administration, and 1 patient noted transient wheezing after administration. The others reported unpleasant local effects, including throat/ear discomfort, voice change, sneezing, reflexive vomiting, and headache. CONCLUSION: In our group of 201 patients with SNC, most of which had failed to respond to standard treatments, 63.7% had some response to capsaicin spray, with 30.8% reporting ≥75% reduction. Minimal side effects of treatment were reported. Thus, we suggest that this therapy can be another treatment option for patients with SNC.
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spelling pubmed-87249982022-01-05 Topical Capsaicin for the Treatment of Sensory Neuropathic Cough Hoesli, Rebecca C. Wingo, Melissa L. Wajsberg, Benjamin Bastian, Robert W. OTO Open Original Research OBJECTIVE: To evaluate a novel treatment for sensory neuropathic cough (SNC): topical capsaicin. STUDY DESIGN: Retrospective review. SETTING: Tertiary care laryngology clinic. METHODS: A retrospective review was performed on 201 consecutive patients treated for SNC with capsaicin 0.02% to 0.04% applied topically to the upper aerodigestive tract, typically after failure of standard medications. Patients were asked to use the spray 4 times daily for 2 weeks prior to assessment of benefit. Items assessed included the percentage reduction of coughing, type of benefit noted, and side effects. RESULTS: Of the 201 patients who used the spray, 36.3% noted no benefit, whereas 63.7% (n = 128) had benefit in terms of cough reduction: 30.8% (n = 62) reported ≥75% reduction; 17.4% (n = 35), 50%-74% reduction; 7.0% (n = 14), 25%-49% reduction; and 8.5% (n = 17), 1%-24% reduction. Of all patients, 78.3% reported no side effects or complications. Of the remaining 21.7%, 1 patient noted a nosebleed after a single administration, and 1 patient noted transient wheezing after administration. The others reported unpleasant local effects, including throat/ear discomfort, voice change, sneezing, reflexive vomiting, and headache. CONCLUSION: In our group of 201 patients with SNC, most of which had failed to respond to standard treatments, 63.7% had some response to capsaicin spray, with 30.8% reporting ≥75% reduction. Minimal side effects of treatment were reported. Thus, we suggest that this therapy can be another treatment option for patients with SNC. SAGE Publications 2021-12-20 /pmc/articles/PMC8724998/ /pubmed/34993384 http://dx.doi.org/10.1177/2473974X211065668 Text en © The Authors 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Hoesli, Rebecca C.
Wingo, Melissa L.
Wajsberg, Benjamin
Bastian, Robert W.
Topical Capsaicin for the Treatment of Sensory Neuropathic Cough
title Topical Capsaicin for the Treatment of Sensory Neuropathic Cough
title_full Topical Capsaicin for the Treatment of Sensory Neuropathic Cough
title_fullStr Topical Capsaicin for the Treatment of Sensory Neuropathic Cough
title_full_unstemmed Topical Capsaicin for the Treatment of Sensory Neuropathic Cough
title_short Topical Capsaicin for the Treatment of Sensory Neuropathic Cough
title_sort topical capsaicin for the treatment of sensory neuropathic cough
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8724998/
https://www.ncbi.nlm.nih.gov/pubmed/34993384
http://dx.doi.org/10.1177/2473974X211065668
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