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Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema
PURPOSE: Advanced glycation end products (AGEs), due to increased production and a slow turnover rate, serve as mediators of “metabolic memory” even after the resolution of hyperglycemia. A prospective study was undertaken to evaluate the association of AGEs with subfoveal ellipsoid zone (EZ) disrup...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725141/ https://www.ncbi.nlm.nih.gov/pubmed/34708772 http://dx.doi.org/10.4103/ijo.IJO_1244_21 |
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author | Mishra, Nibha Singh, Malvika Singh, Rajendra K Saxena, Sandeep |
author_facet | Mishra, Nibha Singh, Malvika Singh, Rajendra K Saxena, Sandeep |
author_sort | Mishra, Nibha |
collection | PubMed |
description | PURPOSE: Advanced glycation end products (AGEs), due to increased production and a slow turnover rate, serve as mediators of “metabolic memory” even after the resolution of hyperglycemia. A prospective study was undertaken to evaluate the association of AGEs with subfoveal ellipsoid zone (EZ) disruption in diabetic macular edema (DME). METHODS: A tertiary-care-center-based cross-sectional study included 40 consecutive cases with DME and 20 healthy controls in the age group of 40–65 years. All the study subjects underwent spectral-domain optical coherence tomography (SD-OCT) for cross-sectional imaging of the retina. The EZ was defined as a hyperreflective band below the external limiting membrane. The disruption of EZ was graded as intact EZ and disrupted EZ. Serum AGEs were assessed by assay of N(ε)-carboxymethyl-lysine (N(ε)-CML) using the standard protocol. Data were analyzed statistically. RESULTS: Subfoveal EZ disruption was noted in 80% (32/40) of the cases of DME. In the cases without EZ disruption, visual acuity (LogMAR VA) was 0.60 ± 0.52, whereas in cases with EZ disruption, LogMAR VA was 0.96 ± 0.56 (P < 0.001). In the cases without EZ disruption, N(ε)-CML was 94.31 ± 57 ng/mL, whereas in cases with EZ disruption N(ε)-CML was 120.64 ± 71.98 ng/mL (P < 0.001). CONCLUSION: In DME, increased levels of AGEs are significantly associated with EZ disruption on SD-OCT. |
format | Online Article Text |
id | pubmed-8725141 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-87251412022-01-20 Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema Mishra, Nibha Singh, Malvika Singh, Rajendra K Saxena, Sandeep Indian J Ophthalmol Original Article PURPOSE: Advanced glycation end products (AGEs), due to increased production and a slow turnover rate, serve as mediators of “metabolic memory” even after the resolution of hyperglycemia. A prospective study was undertaken to evaluate the association of AGEs with subfoveal ellipsoid zone (EZ) disruption in diabetic macular edema (DME). METHODS: A tertiary-care-center-based cross-sectional study included 40 consecutive cases with DME and 20 healthy controls in the age group of 40–65 years. All the study subjects underwent spectral-domain optical coherence tomography (SD-OCT) for cross-sectional imaging of the retina. The EZ was defined as a hyperreflective band below the external limiting membrane. The disruption of EZ was graded as intact EZ and disrupted EZ. Serum AGEs were assessed by assay of N(ε)-carboxymethyl-lysine (N(ε)-CML) using the standard protocol. Data were analyzed statistically. RESULTS: Subfoveal EZ disruption was noted in 80% (32/40) of the cases of DME. In the cases without EZ disruption, visual acuity (LogMAR VA) was 0.60 ± 0.52, whereas in cases with EZ disruption, LogMAR VA was 0.96 ± 0.56 (P < 0.001). In the cases without EZ disruption, N(ε)-CML was 94.31 ± 57 ng/mL, whereas in cases with EZ disruption N(ε)-CML was 120.64 ± 71.98 ng/mL (P < 0.001). CONCLUSION: In DME, increased levels of AGEs are significantly associated with EZ disruption on SD-OCT. Wolters Kluwer - Medknow 2021-11 2021-10-29 /pmc/articles/PMC8725141/ /pubmed/34708772 http://dx.doi.org/10.4103/ijo.IJO_1244_21 Text en Copyright: © 2021 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Mishra, Nibha Singh, Malvika Singh, Rajendra K Saxena, Sandeep Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema |
title | Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema |
title_full | Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema |
title_fullStr | Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema |
title_full_unstemmed | Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema |
title_short | Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema |
title_sort | elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725141/ https://www.ncbi.nlm.nih.gov/pubmed/34708772 http://dx.doi.org/10.4103/ijo.IJO_1244_21 |
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