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Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema

PURPOSE: Advanced glycation end products (AGEs), due to increased production and a slow turnover rate, serve as mediators of “metabolic memory” even after the resolution of hyperglycemia. A prospective study was undertaken to evaluate the association of AGEs with subfoveal ellipsoid zone (EZ) disrup...

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Autores principales: Mishra, Nibha, Singh, Malvika, Singh, Rajendra K, Saxena, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725141/
https://www.ncbi.nlm.nih.gov/pubmed/34708772
http://dx.doi.org/10.4103/ijo.IJO_1244_21
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author Mishra, Nibha
Singh, Malvika
Singh, Rajendra K
Saxena, Sandeep
author_facet Mishra, Nibha
Singh, Malvika
Singh, Rajendra K
Saxena, Sandeep
author_sort Mishra, Nibha
collection PubMed
description PURPOSE: Advanced glycation end products (AGEs), due to increased production and a slow turnover rate, serve as mediators of “metabolic memory” even after the resolution of hyperglycemia. A prospective study was undertaken to evaluate the association of AGEs with subfoveal ellipsoid zone (EZ) disruption in diabetic macular edema (DME). METHODS: A tertiary-care-center-based cross-sectional study included 40 consecutive cases with DME and 20 healthy controls in the age group of 40–65 years. All the study subjects underwent spectral-domain optical coherence tomography (SD-OCT) for cross-sectional imaging of the retina. The EZ was defined as a hyperreflective band below the external limiting membrane. The disruption of EZ was graded as intact EZ and disrupted EZ. Serum AGEs were assessed by assay of N(ε)-carboxymethyl-lysine (N(ε)-CML) using the standard protocol. Data were analyzed statistically. RESULTS: Subfoveal EZ disruption was noted in 80% (32/40) of the cases of DME. In the cases without EZ disruption, visual acuity (LogMAR VA) was 0.60 ± 0.52, whereas in cases with EZ disruption, LogMAR VA was 0.96 ± 0.56 (P < 0.001). In the cases without EZ disruption, N(ε)-CML was 94.31 ± 57 ng/mL, whereas in cases with EZ disruption N(ε)-CML was 120.64 ± 71.98 ng/mL (P < 0.001). CONCLUSION: In DME, increased levels of AGEs are significantly associated with EZ disruption on SD-OCT.
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spelling pubmed-87251412022-01-20 Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema Mishra, Nibha Singh, Malvika Singh, Rajendra K Saxena, Sandeep Indian J Ophthalmol Original Article PURPOSE: Advanced glycation end products (AGEs), due to increased production and a slow turnover rate, serve as mediators of “metabolic memory” even after the resolution of hyperglycemia. A prospective study was undertaken to evaluate the association of AGEs with subfoveal ellipsoid zone (EZ) disruption in diabetic macular edema (DME). METHODS: A tertiary-care-center-based cross-sectional study included 40 consecutive cases with DME and 20 healthy controls in the age group of 40–65 years. All the study subjects underwent spectral-domain optical coherence tomography (SD-OCT) for cross-sectional imaging of the retina. The EZ was defined as a hyperreflective band below the external limiting membrane. The disruption of EZ was graded as intact EZ and disrupted EZ. Serum AGEs were assessed by assay of N(ε)-carboxymethyl-lysine (N(ε)-CML) using the standard protocol. Data were analyzed statistically. RESULTS: Subfoveal EZ disruption was noted in 80% (32/40) of the cases of DME. In the cases without EZ disruption, visual acuity (LogMAR VA) was 0.60 ± 0.52, whereas in cases with EZ disruption, LogMAR VA was 0.96 ± 0.56 (P < 0.001). In the cases without EZ disruption, N(ε)-CML was 94.31 ± 57 ng/mL, whereas in cases with EZ disruption N(ε)-CML was 120.64 ± 71.98 ng/mL (P < 0.001). CONCLUSION: In DME, increased levels of AGEs are significantly associated with EZ disruption on SD-OCT. Wolters Kluwer - Medknow 2021-11 2021-10-29 /pmc/articles/PMC8725141/ /pubmed/34708772 http://dx.doi.org/10.4103/ijo.IJO_1244_21 Text en Copyright: © 2021 Indian Journal of Ophthalmology https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Mishra, Nibha
Singh, Malvika
Singh, Rajendra K
Saxena, Sandeep
Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema
title Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema
title_full Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema
title_fullStr Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema
title_full_unstemmed Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema
title_short Elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema
title_sort elevated advanced glycation end products are associated with subfoveal ellipsoid zone disruption in diabetic macular edema
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725141/
https://www.ncbi.nlm.nih.gov/pubmed/34708772
http://dx.doi.org/10.4103/ijo.IJO_1244_21
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