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Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs)

Objective: Analog triptorelin is one of the effective agonists for the treatment of reproductive disorders, particularly prostate cancer. Due to results of previous studies, we hypothesized that obsessive-compulsive disorder (OCD can be effectively treated with the long-term administration of a gona...

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Autores principales: Nikzad, Faezeh, Sadjadi, Seyed Alireza, Mohammadpour, Amir Hooshang, Ziaee, Maliheh, Behdani, Fatemeh, Naghibi, Seyedeh Maryam, Nejatifard, Seyedeh Narges, Ghanbari, Mahdieh, Akhondpour Manteghi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725189/
https://www.ncbi.nlm.nih.gov/pubmed/35082857
http://dx.doi.org/10.18502/ijps.v16i4.7232
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author Nikzad, Faezeh
Sadjadi, Seyed Alireza
Mohammadpour, Amir Hooshang
Ziaee, Maliheh
Behdani, Fatemeh
Naghibi, Seyedeh Maryam
Nejatifard, Seyedeh Narges
Ghanbari, Mahdieh
Akhondpour Manteghi, Ali
author_facet Nikzad, Faezeh
Sadjadi, Seyed Alireza
Mohammadpour, Amir Hooshang
Ziaee, Maliheh
Behdani, Fatemeh
Naghibi, Seyedeh Maryam
Nejatifard, Seyedeh Narges
Ghanbari, Mahdieh
Akhondpour Manteghi, Ali
author_sort Nikzad, Faezeh
collection PubMed
description Objective: Analog triptorelin is one of the effective agonists for the treatment of reproductive disorders, particularly prostate cancer. Due to results of previous studies, we hypothesized that obsessive-compulsive disorder (OCD can be effectively treated with the long-term administration of a gonadotropin-releasing hormone (GnRH) analog, namely triptorelin. The aim of this study was to evaluate the effectiveness of triptorelin injection in clients with OCD. Method : This randomized single-blind clinical trial was performed on 30 clients with OCD who had a Yale-Brown score of > 17 after 8 weeks of treatment. The participants were randomly assigned into two groups of triptorelin and placebo. The clients in the intervention group were treated with Selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, in addition to triptorelin three times a month for at least 8 weeks. Clients in the control group received injection of distilled water as placebo three times in addition to the routine treatment. The outcome was evaluated by Yale-Brown OCD scale (Y-BOCS) at the baseline, as well as 4, 8, and, 20 weeks after the end of the treatment. Results: The mean scores of Y-BOCS in the intervention and control groups was 30.5 ±67.6 and 30.5 ±67.6, respectively, before intervention, indicating no significant difference between the two groups (P = 0.0.8). The comparison of Y-BOCS scores after the intervention showed a significant difference between the two groups in the scores 4 (P = 0.01), 8 (P < 0.005), and 20 (P < 0.005) weeks after the treatment. With regards to the side effects of the medicine, 6.7% (n = 1) of the clients in the control group developed headache and 66.7% (n = 10) had late period in intervention group. The results revealed a significant difference between the two groups in terms of side effects (P < 0.005). Conclusion: The results of this study showed triptorelin decreased the symptoms of OCD. The effectiveness of triptorelin in the treatment of symptoms in clients with OCD was confirmed in our study. However, due to the limited research addressing this domain, future studies are suggested to clarify this conclusion.
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spelling pubmed-87251892022-01-25 Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs) Nikzad, Faezeh Sadjadi, Seyed Alireza Mohammadpour, Amir Hooshang Ziaee, Maliheh Behdani, Fatemeh Naghibi, Seyedeh Maryam Nejatifard, Seyedeh Narges Ghanbari, Mahdieh Akhondpour Manteghi, Ali Iran J Psychiatry Original Article Objective: Analog triptorelin is one of the effective agonists for the treatment of reproductive disorders, particularly prostate cancer. Due to results of previous studies, we hypothesized that obsessive-compulsive disorder (OCD can be effectively treated with the long-term administration of a gonadotropin-releasing hormone (GnRH) analog, namely triptorelin. The aim of this study was to evaluate the effectiveness of triptorelin injection in clients with OCD. Method : This randomized single-blind clinical trial was performed on 30 clients with OCD who had a Yale-Brown score of > 17 after 8 weeks of treatment. The participants were randomly assigned into two groups of triptorelin and placebo. The clients in the intervention group were treated with Selective serotonin reuptake inhibitors (SSRIs), including fluoxetine, in addition to triptorelin three times a month for at least 8 weeks. Clients in the control group received injection of distilled water as placebo three times in addition to the routine treatment. The outcome was evaluated by Yale-Brown OCD scale (Y-BOCS) at the baseline, as well as 4, 8, and, 20 weeks after the end of the treatment. Results: The mean scores of Y-BOCS in the intervention and control groups was 30.5 ±67.6 and 30.5 ±67.6, respectively, before intervention, indicating no significant difference between the two groups (P = 0.0.8). The comparison of Y-BOCS scores after the intervention showed a significant difference between the two groups in the scores 4 (P = 0.01), 8 (P < 0.005), and 20 (P < 0.005) weeks after the treatment. With regards to the side effects of the medicine, 6.7% (n = 1) of the clients in the control group developed headache and 66.7% (n = 10) had late period in intervention group. The results revealed a significant difference between the two groups in terms of side effects (P < 0.005). Conclusion: The results of this study showed triptorelin decreased the symptoms of OCD. The effectiveness of triptorelin in the treatment of symptoms in clients with OCD was confirmed in our study. However, due to the limited research addressing this domain, future studies are suggested to clarify this conclusion. Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2021-10 /pmc/articles/PMC8725189/ /pubmed/35082857 http://dx.doi.org/10.18502/ijps.v16i4.7232 Text en Copyright © 2021 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Nikzad, Faezeh
Sadjadi, Seyed Alireza
Mohammadpour, Amir Hooshang
Ziaee, Maliheh
Behdani, Fatemeh
Naghibi, Seyedeh Maryam
Nejatifard, Seyedeh Narges
Ghanbari, Mahdieh
Akhondpour Manteghi, Ali
Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs)
title Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs)
title_full Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs)
title_fullStr Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs)
title_full_unstemmed Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs)
title_short Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs)
title_sort adjunct triptorelin in the treatment of obsessive-compulsive disorder in clients receiving selective serotonin reuptake inhibitors (ssris)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725189/
https://www.ncbi.nlm.nih.gov/pubmed/35082857
http://dx.doi.org/10.18502/ijps.v16i4.7232
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