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Decreased mitochondrial D-loop region methylation mediates an increase in mitochondrial DNA copy number in CADASIL

BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a typical neurodegenerative disease associated with mitochondrial dysfunction. Methylation of the D-loop region and mitochondrial DNA copy number (mtDNAcn) play a critical role in the...

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Detalles Bibliográficos
Autores principales:	Zhang, Jiewen, Shang, Junkui, Wang, Fengyu, Huo, Xuejing, Sun, Ruihua, Ren, Zhixia, Wang, Wan, Yang, Miaomiao, Li, Gai, Gao, Dandan, Liu, Ruijie, Bai, Pingping, Wang, Shuyi, Wang, Yanliang, Yan, Xi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725280/ https://www.ncbi.nlm.nih.gov/pubmed/34983647 http://dx.doi.org/10.1186/s13148-021-01225-z

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