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HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

BACKGROUND: The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA). METHODS: Chondrocytes were infected with Ad-m-HDAC4-GFP or...

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Detalles Bibliográficos
Autores principales:	Gu, Xiaodong, Li, Fei, Gao, Yangyang, Che, Xianda, Li, Pengcui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725337/ https://www.ncbi.nlm.nih.gov/pubmed/34980076 http://dx.doi.org/10.1186/s12891-021-04947-6

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