Improved up-and-down procedure for acute toxicity measurement with reliable LD(50) verified by typical toxic alkaloids and modified Karber method

BACKGROUND: Up-and-down procedure (UDP) was recommended to replace traditional acute toxicity methods. However, it was limited due to the long experimental period (20–42 days). To improve UDP, an improved UDP method (iUDP) was developed by shortening observation time between sequence dosages. The ai...

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Detalles Bibliográficos
Autores principales: Zhang, Yan-Yu, Huang, Yu-Feng, Liang, Jie, Zhou, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725450/
https://www.ncbi.nlm.nih.gov/pubmed/34983670
http://dx.doi.org/10.1186/s40360-021-00541-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725450/
https://www.ncbi.nlm.nih.gov/pubmed/34983670
http://dx.doi.org/10.1186/s40360-021-00541-7

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