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Improved up-and-down procedure for acute toxicity measurement with reliable LD(50) verified by typical toxic alkaloids and modified Karber method
BACKGROUND: Up-and-down procedure (UDP) was recommended to replace traditional acute toxicity methods. However, it was limited due to the long experimental period (20–42 days). To improve UDP, an improved UDP method (iUDP) was developed by shortening observation time between sequence dosages. The ai...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725450/ https://www.ncbi.nlm.nih.gov/pubmed/34983670 http://dx.doi.org/10.1186/s40360-021-00541-7 |