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A numerical approach for detecting switch-like bistability in mass action chemical reaction networks with conservation laws

BACKGROUND: Theoretical analysis of signaling pathways can provide a substantial amount of insight into their function. One particular area of research considers signaling pathways capable of assuming two or more stable states given the same amount of signaling ligand. This phenomenon of bistability...

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Detalles Bibliográficos
Autores principales: Reyes, Brandon C, Otero-Muras, Irene, Petyuk, Vladislav A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725470/
https://www.ncbi.nlm.nih.gov/pubmed/34983366
http://dx.doi.org/10.1186/s12859-021-04477-x