Detection of hepatocarcinogens by combination of liver micronucleus assay and histopathological examination in 2-week or 4-week repeated dose studies

BACKGROUND: Currently, revisions to the ICH S1 guidance on rodent carcinogenicity testing are being proposed. Application of this approach would reduce the use of animals in accordance with the 3Rs principles (reduce/refine/replace). The method would also shift resources to focus on more scientific...

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Detalles Bibliográficos
Autores principales: Hamada, Shuichi, Shigano, Miyuki, Wako, Yumi, Kawasako, Kazufumi, Satomoto, Kensuke, Mitsumoto, Tatsuya, Fukuda, Takayuki, Ohyama, Wakako, Morita, Takeshi, Hayashi, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725540/
https://www.ncbi.nlm.nih.gov/pubmed/34983681
http://dx.doi.org/10.1186/s41021-021-00222-1

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