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Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort

BACKGROUND: Growing evidence suggests the relationship between obstructive sleep apnea (OSA) and venous thromboembolism (VTE). Few studies focused on VTE recurrence risk associated with OSA after anticoagulation cessation. METHODS: In a prospective cohort study, patients with documented VTE, were fo...

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Autores principales: Nepveu, Olivier, Orione, Charles, Tromeur, Cécile, Fauché, Alexandre, L’heveder, Cecile, Guegan, Marie, Lemarié, Catherine, Jimenez, David, Leroyer, Christophe, Lacut, Karine, Couturaud, Francis, Le Mao, Raphael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725561/
https://www.ncbi.nlm.nih.gov/pubmed/34983561
http://dx.doi.org/10.1186/s12959-021-00358-8
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author Nepveu, Olivier
Orione, Charles
Tromeur, Cécile
Fauché, Alexandre
L’heveder, Cecile
Guegan, Marie
Lemarié, Catherine
Jimenez, David
Leroyer, Christophe
Lacut, Karine
Couturaud, Francis
Le Mao, Raphael
author_facet Nepveu, Olivier
Orione, Charles
Tromeur, Cécile
Fauché, Alexandre
L’heveder, Cecile
Guegan, Marie
Lemarié, Catherine
Jimenez, David
Leroyer, Christophe
Lacut, Karine
Couturaud, Francis
Le Mao, Raphael
author_sort Nepveu, Olivier
collection PubMed
description BACKGROUND: Growing evidence suggests the relationship between obstructive sleep apnea (OSA) and venous thromboembolism (VTE). Few studies focused on VTE recurrence risk associated with OSA after anticoagulation cessation. METHODS: In a prospective cohort study, patients with documented VTE, were followed for an indefinite length of time and VTE recurrence were documented and adjudicated. The primary outcome was recurrent VTE after anticoagulation discontinuation. Secondary outcomes included all-cause mortality and the clinical presentation of VTE. Univariable and multivariable analyses were performed to identify risk factors for recurrence and mortality. RESULTS: Among the 2109 patients with documented VTE included, 74 patients had moderate to severe OSA diagnosis confirmed by home sleep test or polysomnography. During a median follow-up of 4.8 (interquartile range 2.5–8.0) years recurrent VTE occurred in 252 patients (9 with OSA and 243 without OSA). The recurrence risk in the univariable and multivariable analysis was not increased in patients with OSA, regardless of the time of diagnosis (before or after index VTE or pooled). VTE phenotype was significantly more often PE with or without associated deep vein thrombosis in the first event and recurrence for OSA patients compared to non-OSA patients. The risk of death was not increased in the OSA population compared to non-OSA patients in multivariable analysis. CONCLUSIONS: In patients with OSA and VTE, the risk of all-cause mortality and VTE recurrence after anticoagulation discontinuation was not increased compared to non-OSA patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12959-021-00358-8.
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spelling pubmed-87255612022-01-06 Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort Nepveu, Olivier Orione, Charles Tromeur, Cécile Fauché, Alexandre L’heveder, Cecile Guegan, Marie Lemarié, Catherine Jimenez, David Leroyer, Christophe Lacut, Karine Couturaud, Francis Le Mao, Raphael Thromb J Research BACKGROUND: Growing evidence suggests the relationship between obstructive sleep apnea (OSA) and venous thromboembolism (VTE). Few studies focused on VTE recurrence risk associated with OSA after anticoagulation cessation. METHODS: In a prospective cohort study, patients with documented VTE, were followed for an indefinite length of time and VTE recurrence were documented and adjudicated. The primary outcome was recurrent VTE after anticoagulation discontinuation. Secondary outcomes included all-cause mortality and the clinical presentation of VTE. Univariable and multivariable analyses were performed to identify risk factors for recurrence and mortality. RESULTS: Among the 2109 patients with documented VTE included, 74 patients had moderate to severe OSA diagnosis confirmed by home sleep test or polysomnography. During a median follow-up of 4.8 (interquartile range 2.5–8.0) years recurrent VTE occurred in 252 patients (9 with OSA and 243 without OSA). The recurrence risk in the univariable and multivariable analysis was not increased in patients with OSA, regardless of the time of diagnosis (before or after index VTE or pooled). VTE phenotype was significantly more often PE with or without associated deep vein thrombosis in the first event and recurrence for OSA patients compared to non-OSA patients. The risk of death was not increased in the OSA population compared to non-OSA patients in multivariable analysis. CONCLUSIONS: In patients with OSA and VTE, the risk of all-cause mortality and VTE recurrence after anticoagulation discontinuation was not increased compared to non-OSA patients. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12959-021-00358-8. BioMed Central 2022-01-04 /pmc/articles/PMC8725561/ /pubmed/34983561 http://dx.doi.org/10.1186/s12959-021-00358-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Nepveu, Olivier
Orione, Charles
Tromeur, Cécile
Fauché, Alexandre
L’heveder, Cecile
Guegan, Marie
Lemarié, Catherine
Jimenez, David
Leroyer, Christophe
Lacut, Karine
Couturaud, Francis
Le Mao, Raphael
Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort
title Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort
title_full Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort
title_fullStr Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort
title_full_unstemmed Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort
title_short Association between obstructive sleep apnea and venous thromboembolism recurrence: results from a French cohort
title_sort association between obstructive sleep apnea and venous thromboembolism recurrence: results from a french cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725561/
https://www.ncbi.nlm.nih.gov/pubmed/34983561
http://dx.doi.org/10.1186/s12959-021-00358-8
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