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Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate–induced colitis in mice lacking microsomal prostaglandin E synthase-1

BACKGROUND: Microsomal prostaglandin E synthase-1 (mPGES-1) is a key enzyme that acts downstream of cyclooxygenase and plays a major role in inflammation by converting prostaglandin (PG) H(2) to PGE(2). The present study investigated the effect of genetic deletion of mPGES-1 on the development of im...

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Detalles Bibliográficos
Autores principales:	Kojima, Fumiaki, Sekiya, Hiroki, Hioki, Yuka, Kashiwagi, Hitoshi, Kubo, Makoto, Nakamura, Masaki, Maehana, Shotaro, Imamichi, Yoshitaka, Yuhki, Koh-ichi, Ushikubi, Fumitaka, Kitasato, Hidero, Ichikawa, Takafumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725565/ https://www.ncbi.nlm.nih.gov/pubmed/34983695 http://dx.doi.org/10.1186/s41232-021-00188-1

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