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PixR, a Novel Activator of Conjugative Transfer of IncX4 Resistance Plasmids, Mitigates the Fitness Cost of mcr-1 Carriage in Escherichia coli
The emergence of the plasmid-borne colistin resistance gene mcr-1 threatens public health. IncX4-type plasmids are one of the most epidemiologically successful vehicles for spreading mcr-1 worldwide. Since MCR-1 is known for imposing a fitness cost to its host bacterium, the successful spread of mcr...
Autores principales: | Yi, Lingxian, Durand, Romain, Grenier, Frédéric, Yang, Jun, Yu, Kaiyang, Burrus, Vincent, Liu, Jian-Hua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725589/ https://www.ncbi.nlm.nih.gov/pubmed/35089067 http://dx.doi.org/10.1128/mbio.03209-21 |
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