Polycyclic nitrogen heterocycles as potential thymidine phosphorylase inhibitors: synthesis, biological evaluation, and molecular docking study

New polycyclic heterocycles were synthesised and evaluated as potential inhibitors of thymidine phosphorylase (TP). Inspired by the pharmacophoric pyrimidinedione core of the natural substrate, four series have been designed in order to interact with large empty pockets of the active site: pyrimidoq...

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Detalles Bibliográficos
Autores principales: Aknin, Karen, Bontemps, Alexis, Farce, Amaury, Merlet, Eric, Belmont, Philippe, Helissey, Philippe, Chavatte, Philippe, Sari, Marie-Agnès, Giorgi-Renault, Sylviane, Desbène-Finck, Stéphanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725971/
https://www.ncbi.nlm.nih.gov/pubmed/34933639
http://dx.doi.org/10.1080/14756366.2021.2001806

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