Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in...

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Detalles Bibliográficos
Autores principales: Horvat, Melissa, Weilch, Victoria, Rädisch, Robert, Hecko, Sebastian, Schiefer, Astrid, Rudroff, Florian, Wilding, Birgit, Klempier, Norbert, Pátek, Miroslav, Martínková, Ludmila, Winkler, Margit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725990/
https://www.ncbi.nlm.nih.gov/pubmed/35126993
http://dx.doi.org/10.1039/d1cy01694f
Descripción
Sumario:We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.

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