Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime

We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in...

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Autores principales: Horvat, Melissa, Weilch, Victoria, Rädisch, Robert, Hecko, Sebastian, Schiefer, Astrid, Rudroff, Florian, Wilding, Birgit, Klempier, Norbert, Pátek, Miroslav, Martínková, Ludmila, Winkler, Margit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725990/
https://www.ncbi.nlm.nih.gov/pubmed/35126993
http://dx.doi.org/10.1039/d1cy01694f
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author Horvat, Melissa
Weilch, Victoria
Rädisch, Robert
Hecko, Sebastian
Schiefer, Astrid
Rudroff, Florian
Wilding, Birgit
Klempier, Norbert
Pátek, Miroslav
Martínková, Ludmila
Winkler, Margit
author_facet Horvat, Melissa
Weilch, Victoria
Rädisch, Robert
Hecko, Sebastian
Schiefer, Astrid
Rudroff, Florian
Wilding, Birgit
Klempier, Norbert
Pátek, Miroslav
Martínková, Ludmila
Winkler, Margit
author_sort Horvat, Melissa
collection PubMed
description We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode.
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spelling pubmed-87259902022-02-04 Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime Horvat, Melissa Weilch, Victoria Rädisch, Robert Hecko, Sebastian Schiefer, Astrid Rudroff, Florian Wilding, Birgit Klempier, Norbert Pátek, Miroslav Martínková, Ludmila Winkler, Margit Catal Sci Technol Chemistry We report a new chemoenzymatic cascade starting with aldehyde synthesis by carboxylic acid reductase (CAR) followed by chemical in situ oxime formation. The final step to the nitrile is catalyzed by aldoxime dehydratase (Oxd). Full conversions of phenylacetic acid and hexanoic acid were achieved in a two-phase mode. The Royal Society of Chemistry 2021-11-30 /pmc/articles/PMC8725990/ /pubmed/35126993 http://dx.doi.org/10.1039/d1cy01694f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by/3.0/
spellingShingle Chemistry
Horvat, Melissa
Weilch, Victoria
Rädisch, Robert
Hecko, Sebastian
Schiefer, Astrid
Rudroff, Florian
Wilding, Birgit
Klempier, Norbert
Pátek, Miroslav
Martínková, Ludmila
Winkler, Margit
Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
title Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
title_full Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
title_fullStr Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
title_full_unstemmed Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
title_short Chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
title_sort chemoenzymatic one-pot reaction from carboxylic acid to nitrile via oxime
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8725990/
https://www.ncbi.nlm.nih.gov/pubmed/35126993
http://dx.doi.org/10.1039/d1cy01694f
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