Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology

The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for th...

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Detalles Bibliográficos
Autores principales: Epple, Sven, El-Sagheer, Afaf H., Brown, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726046/
https://www.ncbi.nlm.nih.gov/pubmed/34297063
http://dx.doi.org/10.1042/ETLS20210169
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author Epple, Sven
El-Sagheer, Afaf H.
Brown, Tom
author_facet Epple, Sven
El-Sagheer, Afaf H.
Brown, Tom
author_sort Epple, Sven
collection PubMed
description The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleotides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology.
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spelling pubmed-87260462022-01-12 Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology Epple, Sven El-Sagheer, Afaf H. Brown, Tom Emerg Top Life Sci Perspective The modification of DNA or RNA backbones is an emerging technology for therapeutic oligonucleotides, synthetic biology and biotechnology. Despite a plethora of reported artificial backbones, their vast potential is not fully utilised. Limited synthetic accessibility remains a major bottleneck for the wider application of backbone-modified oligonucleotides. Thus, a variety of readily accessible artificial backbones and robust methods for their introduction into oligonucleotides are urgently needed to utilise their full potential in therapeutics, synthetic biology and biotechnology. Portland Press Ltd. 2021-11-12 2021-07-23 /pmc/articles/PMC8726046/ /pubmed/34297063 http://dx.doi.org/10.1042/ETLS20210169 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and the Royal Society of Biology and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . Open access for this article was enabled by the participation of University of Oxford in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with JISC.
spellingShingle Perspective
Epple, Sven
El-Sagheer, Afaf H.
Brown, Tom
Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
title Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
title_full Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
title_fullStr Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
title_full_unstemmed Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
title_short Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
title_sort artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726046/
https://www.ncbi.nlm.nih.gov/pubmed/34297063
http://dx.doi.org/10.1042/ETLS20210169
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