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Individually selected teletherapy technique for accelerated partial breast irradiation
BACKGROUND: The aim of the study was to individualize accelerated partial breast irradiation based on optimal dose distribution, protect risk organ and predict most advantageous technique. MATERIALS AND METHODS: 138 breast cancer patients receiving postoperative APBI were enrolled. APBI plans were g...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Via Medica
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726449/ https://www.ncbi.nlm.nih.gov/pubmed/34992873 http://dx.doi.org/10.5603/RPOR.a2021.0123 |
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author | Kószó, Renáta L. Kahán, Zsuzsanna Darázs, Barbara Rárosi, Ferenc Varga, Zoltán |
author_facet | Kószó, Renáta L. Kahán, Zsuzsanna Darázs, Barbara Rárosi, Ferenc Varga, Zoltán |
author_sort | Kószó, Renáta L. |
collection | PubMed |
description | BACKGROUND: The aim of the study was to individualize accelerated partial breast irradiation based on optimal dose distribution, protect risk organ and predict most advantageous technique. MATERIALS AND METHODS: 138 breast cancer patients receiving postoperative APBI were enrolled. APBI plans were generated using 3D-conformal (3D-CRT), sliding window intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT). In the case of superficial tumours, additional plans were developed by adding electron beam. To planning target volume (PTV) 37.5 Gy/10 fractions, 1 fraction/day was prescribed. A novel plan quality index (PQI) served as the basis for comparisons. RESULTS: IMRT was the most advantageous technique regarding homogeneity. VMAT provided best conformity, 3D-CR T — the lowest lung and heart exposure. PQI was the best in 45 (32.61%) VMAT, 13 (9.42%) IMRT, 9 (6.52%) 3D-CRT plans. In 71 cases (51.45%) no difference was detected. In patients with large PTV, 3D-CRT was the most favourable. Additional electron beam improved PQI of 3D-CRT plans but had no meaningful effect on IMRT or VMAT. IMRT was superior to VMAT if the tumour was superficial (p < 0.001), situated in the medial (p = 0.032) or upper quadrant (p = 0.046). CONCLUSIONS: In half of all cases, individually selected teletherapy techniques provide superior results over others; relevance of a certain technique may be predicted by volume and PTV localization. |
format | Online Article Text |
id | pubmed-8726449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Via Medica |
record_format | MEDLINE/PubMed |
spelling | pubmed-87264492022-01-05 Individually selected teletherapy technique for accelerated partial breast irradiation Kószó, Renáta L. Kahán, Zsuzsanna Darázs, Barbara Rárosi, Ferenc Varga, Zoltán Rep Pract Oncol Radiother Research Paper BACKGROUND: The aim of the study was to individualize accelerated partial breast irradiation based on optimal dose distribution, protect risk organ and predict most advantageous technique. MATERIALS AND METHODS: 138 breast cancer patients receiving postoperative APBI were enrolled. APBI plans were generated using 3D-conformal (3D-CRT), sliding window intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT). In the case of superficial tumours, additional plans were developed by adding electron beam. To planning target volume (PTV) 37.5 Gy/10 fractions, 1 fraction/day was prescribed. A novel plan quality index (PQI) served as the basis for comparisons. RESULTS: IMRT was the most advantageous technique regarding homogeneity. VMAT provided best conformity, 3D-CR T — the lowest lung and heart exposure. PQI was the best in 45 (32.61%) VMAT, 13 (9.42%) IMRT, 9 (6.52%) 3D-CRT plans. In 71 cases (51.45%) no difference was detected. In patients with large PTV, 3D-CRT was the most favourable. Additional electron beam improved PQI of 3D-CRT plans but had no meaningful effect on IMRT or VMAT. IMRT was superior to VMAT if the tumour was superficial (p < 0.001), situated in the medial (p = 0.032) or upper quadrant (p = 0.046). CONCLUSIONS: In half of all cases, individually selected teletherapy techniques provide superior results over others; relevance of a certain technique may be predicted by volume and PTV localization. Via Medica 2021-12-30 /pmc/articles/PMC8726449/ /pubmed/34992873 http://dx.doi.org/10.5603/RPOR.a2021.0123 Text en © 2021 Greater Poland Cancer Centre https://creativecommons.org/licenses/by-nc-nd/4.0/This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially |
spellingShingle | Research Paper Kószó, Renáta L. Kahán, Zsuzsanna Darázs, Barbara Rárosi, Ferenc Varga, Zoltán Individually selected teletherapy technique for accelerated partial breast irradiation |
title | Individually selected teletherapy technique for accelerated partial breast irradiation |
title_full | Individually selected teletherapy technique for accelerated partial breast irradiation |
title_fullStr | Individually selected teletherapy technique for accelerated partial breast irradiation |
title_full_unstemmed | Individually selected teletherapy technique for accelerated partial breast irradiation |
title_short | Individually selected teletherapy technique for accelerated partial breast irradiation |
title_sort | individually selected teletherapy technique for accelerated partial breast irradiation |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726449/ https://www.ncbi.nlm.nih.gov/pubmed/34992873 http://dx.doi.org/10.5603/RPOR.a2021.0123 |
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