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HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly

Sonic Hedgehog/GLI3 signaling is critical in regulating digit number, such that Gli3-deficiency results in polydactyly and Shh-deficiency leads to digit number reductions. SHH/GLI3 signaling regulates cell cycle factors controlling mesenchymal cell proliferation, while simultaneously regulating Grem...

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Detalles Bibliográficos
Autores principales:	Sharma, Deepika, Mirando, Anthony J., Leinroth, Abigail, Long, Jason T., Karner, Courtney M., Hilton, Matthew J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726490/ https://www.ncbi.nlm.nih.gov/pubmed/34928956 http://dx.doi.org/10.1371/journal.pgen.1009982

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