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Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population
BACKGROUND AND OBJECTIVES: To investigate sociodemographic and medical predictors of incident mild cognitive impairment (MCI) and subsequent course of MCI at follow-up, including sustained MCI diagnosis, classification as cognitively normal, and progression to dementia. METHODS: Within a community-b...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726570/ https://www.ncbi.nlm.nih.gov/pubmed/34853178 http://dx.doi.org/10.1212/WNL.0000000000013017 |
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author | Angevaare, Milou J. Vonk, Jet M.J. Bertola, Laiss Zahodne, Laura Watson, Caitlin Wei-Ming Boehme, Amelia Schupf, Nicole Mayeux, Richard Geerlings, Mirjam I. Manly, Jennifer J. |
author_facet | Angevaare, Milou J. Vonk, Jet M.J. Bertola, Laiss Zahodne, Laura Watson, Caitlin Wei-Ming Boehme, Amelia Schupf, Nicole Mayeux, Richard Geerlings, Mirjam I. Manly, Jennifer J. |
author_sort | Angevaare, Milou J. |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: To investigate sociodemographic and medical predictors of incident mild cognitive impairment (MCI) and subsequent course of MCI at follow-up, including sustained MCI diagnosis, classification as cognitively normal, and progression to dementia. METHODS: Within a community-based cohort, diagnoses of MCI were made with a published algorithm. Diagnosis of dementia was based on clinical consensus. Cox regressions estimated hazard ratios of incident MCI associated with several predictors. Modified Poisson regressions estimated relative risks associated with predictors of diagnostic status at follow-up after incidence. RESULTS: Among 2,903 cognitively normal participants at baseline, 752 developed MCI over an average of 6.3 (SD 4.5) years (incidence rate 56 per 1,000 person-years). Presence of APOE ε4 and higher medical burden increased risk of incident MCI, while more years of education, more leisure activities, and higher income decreased this risk. Of the incident MCI cases, after an average of 2.4 years of follow-up, 12.9% progressed to dementia, 9.6% declined in functioning and did not meet the algorithmic criteria for MCI but did not meet the clinical criteria for dementia, 29.6% continued to meet MCI criteria, and 47.9% no longer met MCI criteria. Multidomain MCI, presence of APOE ε4, depressive symptoms, and antidepressant use increased the risk of progression to dementia. DISCUSSION: This community-based study showed that almost half of the individuals with incident MCI diagnoses were classified as cognitively normal at follow-up. Predictors of incident MCI demonstrably differed from those of subsequent MCI course; these findings can refine expectations for cognitive and functional course of those presenting with MCI. |
format | Online Article Text |
id | pubmed-8726570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-87265702022-01-13 Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population Angevaare, Milou J. Vonk, Jet M.J. Bertola, Laiss Zahodne, Laura Watson, Caitlin Wei-Ming Boehme, Amelia Schupf, Nicole Mayeux, Richard Geerlings, Mirjam I. Manly, Jennifer J. Neurology Research Article BACKGROUND AND OBJECTIVES: To investigate sociodemographic and medical predictors of incident mild cognitive impairment (MCI) and subsequent course of MCI at follow-up, including sustained MCI diagnosis, classification as cognitively normal, and progression to dementia. METHODS: Within a community-based cohort, diagnoses of MCI were made with a published algorithm. Diagnosis of dementia was based on clinical consensus. Cox regressions estimated hazard ratios of incident MCI associated with several predictors. Modified Poisson regressions estimated relative risks associated with predictors of diagnostic status at follow-up after incidence. RESULTS: Among 2,903 cognitively normal participants at baseline, 752 developed MCI over an average of 6.3 (SD 4.5) years (incidence rate 56 per 1,000 person-years). Presence of APOE ε4 and higher medical burden increased risk of incident MCI, while more years of education, more leisure activities, and higher income decreased this risk. Of the incident MCI cases, after an average of 2.4 years of follow-up, 12.9% progressed to dementia, 9.6% declined in functioning and did not meet the algorithmic criteria for MCI but did not meet the clinical criteria for dementia, 29.6% continued to meet MCI criteria, and 47.9% no longer met MCI criteria. Multidomain MCI, presence of APOE ε4, depressive symptoms, and antidepressant use increased the risk of progression to dementia. DISCUSSION: This community-based study showed that almost half of the individuals with incident MCI diagnoses were classified as cognitively normal at follow-up. Predictors of incident MCI demonstrably differed from those of subsequent MCI course; these findings can refine expectations for cognitive and functional course of those presenting with MCI. Lippincott Williams & Wilkins 2022-01-04 /pmc/articles/PMC8726570/ /pubmed/34853178 http://dx.doi.org/10.1212/WNL.0000000000013017 Text en Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Research Article Angevaare, Milou J. Vonk, Jet M.J. Bertola, Laiss Zahodne, Laura Watson, Caitlin Wei-Ming Boehme, Amelia Schupf, Nicole Mayeux, Richard Geerlings, Mirjam I. Manly, Jennifer J. Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population |
title | Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population |
title_full | Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population |
title_fullStr | Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population |
title_full_unstemmed | Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population |
title_short | Predictors of Incident Mild Cognitive Impairment and Its Course in a Diverse Community-Based Population |
title_sort | predictors of incident mild cognitive impairment and its course in a diverse community-based population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726570/ https://www.ncbi.nlm.nih.gov/pubmed/34853178 http://dx.doi.org/10.1212/WNL.0000000000013017 |
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