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FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway
Presbycusis is the cumulative effect of aging on hearing. Recent studies have shown that common mitochondrial gene deletions are closely related to deafness caused by degenerative changes in the auditory system, and some of these nuclear factors are proposed to participate in the regulation of mitoc...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726647/ https://www.ncbi.nlm.nih.gov/pubmed/34006186 http://dx.doi.org/10.1080/15548627.2021.1916194 |
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author | He, Zu-Hong Li, Ming Fang, Qiao-Jun Liao, Fu-Ling Zou, Sheng-Yu Wu, Xia Sun, Hai-Ying Zhao, Xue-Yan Hu, Yu-Juan Xu, Xiao-Xiang Chen, Sen Sun, Yu Chai, Ren-Jie Kong, Wei-Jia |
author_facet | He, Zu-Hong Li, Ming Fang, Qiao-Jun Liao, Fu-Ling Zou, Sheng-Yu Wu, Xia Sun, Hai-Ying Zhao, Xue-Yan Hu, Yu-Juan Xu, Xiao-Xiang Chen, Sen Sun, Yu Chai, Ren-Jie Kong, Wei-Jia |
author_sort | He, Zu-Hong |
collection | PubMed |
description | Presbycusis is the cumulative effect of aging on hearing. Recent studies have shown that common mitochondrial gene deletions are closely related to deafness caused by degenerative changes in the auditory system, and some of these nuclear factors are proposed to participate in the regulation of mitochondrial function. However, the detailed mechanisms involved in age-related degeneration of the auditory systems have not yet been fully elucidated. In this study, we found that FOXG1 plays an important role in the auditory degeneration process through regulation of macroautophagy/autophagy. Inhibition of FOXG1 decreased the autophagy activity and led to the accumulation of reactive oxygen species and subsequent apoptosis of cochlear hair cells. Recent clinical studies have found that aspirin plays important roles in the prevention and treatment of various diseases by regulating autophagy and mitochondria function. In this study, we found that aspirin increased the expression of FOXG1, which further activated autophagy and reduced the production of reactive oxygen species and inhibited apoptosis, and thus promoted the survival of mimetic aging HCs and HC-like OC-1 cells. This study demonstrates the regulatory function of the FOXG1 transcription factor through the autophagy pathway during hair cell degeneration in presbycusis, and it provides a new molecular approach for the treatment of age-related hearing loss. Abbreviations: AHL: age-related hearing loss; baf: bafilomycin A1; CD: common deletion; D-gal: D-galactose; GO: glucose oxidase; HC: hair cells; mtDNA: mitochondrial DNA; RAP: rapamycin; ROS: reactive oxygen species; TMRE: tetramethylrhodamine, ethyl ester |
format | Online Article Text |
id | pubmed-8726647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-87266472022-01-05 FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway He, Zu-Hong Li, Ming Fang, Qiao-Jun Liao, Fu-Ling Zou, Sheng-Yu Wu, Xia Sun, Hai-Ying Zhao, Xue-Yan Hu, Yu-Juan Xu, Xiao-Xiang Chen, Sen Sun, Yu Chai, Ren-Jie Kong, Wei-Jia Autophagy Research Paper Presbycusis is the cumulative effect of aging on hearing. Recent studies have shown that common mitochondrial gene deletions are closely related to deafness caused by degenerative changes in the auditory system, and some of these nuclear factors are proposed to participate in the regulation of mitochondrial function. However, the detailed mechanisms involved in age-related degeneration of the auditory systems have not yet been fully elucidated. In this study, we found that FOXG1 plays an important role in the auditory degeneration process through regulation of macroautophagy/autophagy. Inhibition of FOXG1 decreased the autophagy activity and led to the accumulation of reactive oxygen species and subsequent apoptosis of cochlear hair cells. Recent clinical studies have found that aspirin plays important roles in the prevention and treatment of various diseases by regulating autophagy and mitochondria function. In this study, we found that aspirin increased the expression of FOXG1, which further activated autophagy and reduced the production of reactive oxygen species and inhibited apoptosis, and thus promoted the survival of mimetic aging HCs and HC-like OC-1 cells. This study demonstrates the regulatory function of the FOXG1 transcription factor through the autophagy pathway during hair cell degeneration in presbycusis, and it provides a new molecular approach for the treatment of age-related hearing loss. Abbreviations: AHL: age-related hearing loss; baf: bafilomycin A1; CD: common deletion; D-gal: D-galactose; GO: glucose oxidase; HC: hair cells; mtDNA: mitochondrial DNA; RAP: rapamycin; ROS: reactive oxygen species; TMRE: tetramethylrhodamine, ethyl ester Taylor & Francis 2021-05-19 /pmc/articles/PMC8726647/ /pubmed/34006186 http://dx.doi.org/10.1080/15548627.2021.1916194 Text en © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Research Paper He, Zu-Hong Li, Ming Fang, Qiao-Jun Liao, Fu-Ling Zou, Sheng-Yu Wu, Xia Sun, Hai-Ying Zhao, Xue-Yan Hu, Yu-Juan Xu, Xiao-Xiang Chen, Sen Sun, Yu Chai, Ren-Jie Kong, Wei-Jia FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway |
title | FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway |
title_full | FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway |
title_fullStr | FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway |
title_full_unstemmed | FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway |
title_short | FOXG1 promotes aging inner ear hair cell survival through activation of the autophagy pathway |
title_sort | foxg1 promotes aging inner ear hair cell survival through activation of the autophagy pathway |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726647/ https://www.ncbi.nlm.nih.gov/pubmed/34006186 http://dx.doi.org/10.1080/15548627.2021.1916194 |
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