Development of a nonhuman primate challenge model to evaluate CD8(+) T cell responses to an adenovirus-based vaccine expressing SIV proteins upon repeat-dose treatment with checkpoint inhibitors

Targeting immune checkpoint receptors expressed in the T cell synapse induces active and long-lasting antitumor immunity in preclinical tumor models and oncology patients. However, traditional nonhuman primate (NHP) studies in healthy animals have thus far demonstrated little to no pharmacological a...

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Detalles Bibliográficos
Autores principales: Graveline, Richard, Haida, Morad, Dumont, Carolyne, Poulin, Dominic, Poitout-Belissent, Florence, Samadfam, Rana, Kronenberg, Sven, Regenass-Lechner, Franziska, Prell, Rodney, Piche, Marie-Soleil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8726661/
https://www.ncbi.nlm.nih.gov/pubmed/34923919
http://dx.doi.org/10.1080/19420862.2021.1979447

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